The inhibitory potency of the series of inhibitors of the soluble epoxide hydrolase (sEH) based on the selenourea moiety and containing adamantane and aromatic lipophilic groups ranges from 34.3 nM to 1.2 μM.
View Article and Find Full Text PDFNatural or synthetic antioxidants with biomimetic fragments protect the functional and structural integrity of biological molecules at a minimum concentration, and may be used as potential chemotherapeutic agents. This paper is devoted to in silico and in vitro evaluation of the antioxidant and cytotoxic properties of synthetic analogues of natural compounds-aromatic oligosulfides. The antiradical and SOD-protective activity of oligosulfides was demonstrated in the reaction with O generated in enzymatic and non-enzymatic systems.
View Article and Find Full Text PDFOver recent years, quantum dots (QDs) based on ternary metal dichalcogenides have attracted a lot of attention due to their unique properties and a range of potential applications. Here, we review the latest studies on the optical properties of AgInS/ZnS QDs with emphasis on their theoretical modeling, and present our investigations of electronic transitions invisible in unstructured absorption spectra of AgInS/ZnS QDs. The analysis of the absorption, photoluminescence excitation (PLE), and magnetic circular dichroism (MCD) spectra of hydrophobic and hydrophilic AgInS/ZnS QDs of different sizes enables us to determine positions of electron transitions in these QDs.
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