The association between obsessive compulsive disorder and obsessive compulsive personality disorder: prevalence and clinical presentation.

Objectives: The relationship between Obsessive Compulsive Disorder (OCD) and Obsessive Compulsive Personality Disorder (OCPD) has been the subject of interest for some time due to the historical assumption that OCPD causes OCD. This study systematically examined the association between OCD and OCPD in terms of prevalence and clinical presentation. The specificity of the association between OCD and OCPD was investigated relative to another axis I anxiety disorder (Panic disorder).

Beliefs and experiences in hoarding.

Recent research suggests that hoarding problems may be relatively heterogeneous, with the suggestion that three belief dimensions may underpin hoarding experiences, namely harm avoidance, fear of material deprivation, and heightened "sentimentality" in relation to possessions. The role of these hypothesised belief dimensions in hoarding was evaluated in this study, together with the association between compulsive hoarding and OCD on several clinically relevant variables. As hypothesised, individuals with hoarding and co-existing OCD reported greater harm avoidance beliefs in relation to possessions compared with a group of hoarders without OCD.

Regioselective C2-arylation of imidazo[4,5-b]pyridines.

We show that N3-MEM-protected imidazo[4,5-b]pyridines undergo efficient C2-functionalisation via direct C-H arylation. Twenty-two substituted imidazo[4,5-b]pyridines are prepared and iterative, selective elaboration of functionalised imidazo[4,5-b]pyridines gives 2,7- and 2,6-disubstituted derivatives in good yields from common intermediates. Mechanistic observations are consistent with a concerted-metallation-deprotonation mechanism facilitated by coordination of copper(I)iodide to the imidazo[4,5-b]pyridine.

Time-intensive cognitive behaviour therapy for obsessive-compulsive disorder: A case series and matched comparison group.

Objectives: A time-intensive format may be both useful and effective for the delivery of cognitive behaviour therapy (CBT) for obsessive-compulsive disorder (OCD). Intensive treatments also offer a pragmatic alternative to in-patient admission for those in a geographically remote location. Published studies of intensive treatment include pioneering exposure-response prevention (ERP) trials that emphasized the requirement for high-intensity treatment; more recently several studies have used treatment protocols with a heavy emphasis on ERP.

Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution.

Pin1 is an emerging oncology target strongly implicated in Ras and ErbB2-mediated tumourigenesis. Pin1 isomerizes bonds linking phospho-serine/threonine moieties to proline enabling it to play a key role in proline-directed kinase signalling. Here we report a novel series of Pin1 inhibitors based on a phenyl imidazole acid core that contains sub-μM inhibitors.

The impact of symptomatic hoarding in OCD and its treatment.

Background: The value of defining subtypes in obsessive compulsive disorder (OCD) has become an important issue for recent debate. Probably the most robust example of subtyping is the identification of hoarding as being different both in terms of psychopathology and response to treatment.

Aims: To identify differences in psychopathology and treatment response in OCD patients with and without additional hoarding symptoms.

Regulating intensity using perceived exertion in spinal cord-injured participants.

Purpose: To examine the validity of perception-based intensity regulation during handcycling exercise.

Methods: Eight spinal cord-injured (T11 incomplete to T4 complete) participants completed an incremental exercise test followed by a (.)VO2peak test using a sports hand bike.

A qualitative study of the acceptability of an intensive format for the delivery of cognitive-behavioural therapy for obsessive-compulsive disorder.

Objectives: An intensive format may be both useful and effective for the delivery of cognitive-behavioural therapy (CBT) for obsessive-compulsive disorder (OCD). However, the acceptability of an intensive treatment format from the perspective of service users is unknown. This study examines service user perspectives on the acceptability of an intensive versus a standard weekly treatment format.

Clinical and treatment comparisons between adults with early- and late-onset obsessive-compulsive disorder.

It is often suggested that early onset of disorders leads to higher severity and greater treatment refractoriness. Previous research has investigated whether there are clinical and demographic differences between groups of individuals who have experienced onset of obsessive-compulsive disorder (OCD) at an early or later age. Results suggest that individuals who report an early onset (EO) of the disorder report greater severity and persistence of symptoms.