Publications by authors named "Victoria Mountain"
Article Synopsis
- * Researchers used machine learning and advanced analysis of tissue samples from NASH clinical trials to identify a 5-gene expression signature that could predict disease progression in patients with severe liver fibrosis (F3 and F4 stages).
- * This study found that the Notch signaling pathway, linked to liver diseases, was significantly present in the gene signature, and in a validation cohort, drugs that improved liver conditions also reduced levels of various Notch signaling components.
Article Synopsis
- Computational methods have enhanced pathology workflows for diagnostics and genomics but struggle with interpretability for clinical use.
- We developed a method using human-interpretable image features (HIFs) from histopathology images, trained on over 1.6 million annotations from certified pathologists.
- Our approach identifies specific cancer-related characteristics and predicts molecular signatures with similar accuracy to complex 'black-box' models, offering clear insights into tumor microenvironments.
