Three major subsets constitute the dendritic cells (DCs) pool in the thymus. They play key roles in self-antigen-specific thymocyte deletion and in the development of immunoregulatory T cells. Resident SIRPa conventional DCs (cDCs, CD11c PDCA1 ) are derived from intrathymic progenitors, whereas migratory SIRPa cDCs and plasmacytoid DCs (pDCs, CD11c PDCA1 ) originate from extrathymic sites.
View Article and Find Full Text PDFExtrathymic T cell precursors can be detected in many tissues and represent an immediately competent population for rapid T cell reconstitution in the event of immunodeficiencies. Blood T cell progenitors have been detected, but their source in the bone marrow (BM) remains unclear. Prospective purification of BM-resident and circulating progenitors, together with RT-PCR single-cell analysis, was used to evaluate and compare multipotent progenitors (MPPs) and common lymphoid progenitors (CLPs).
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