Angiomyolipomatous Lesions of the Nasal Cavity (Sinonasal Angioleiomyoma with Adipocytic Differentiation): A Multi-Institutional Immunohistochemical and Molecular Study.

Purpose: Mesenchymal neoplasms composed of vascular, smooth muscle, and adipocytic components are uncommon in the nasal cavity. While angioleiomyoma (AL) is a smooth muscle tumor in the Head & Neck WHO classification, it is considered of pericytic origin in the Skin as well as Soft Tissue and Bone classifications. For nasal AL with an adipocytic component, the terms AL with adipocytic differentiation and angiomyolipoma (AML) have been applied, among others.

A Pineal Parenchymal Tumor of Intermediate Differentiation in an Octogenarian Contains a Rare Insertion.

Pineal parenchymal tumors are rare central nervous system tumors that pose diagnostic challenges for surgical pathologists. Due to their paucity, their clinicopathologic features are still being defined. We report an 86-year-old woman with a remote history of breast lobular carcinoma who presented with a 2-month neurologic history that included gait instability, blurry vision, and headaches.

Cytopathological characteristics of solitary fibrous tumour involving the pancreas by fine needle aspiration: Making an accurate preoperative diagnosis in an uncommon location.

Background: Solitary fibrous tumour (SFT) is a unique mesenchymal neoplasm with classic features on histology and is characterised by the NAB2-STAT6 gene fusion. There are rare reports of SFTs with pancreatic involvement and only two cases in the literature reporting its features by preoperative fine needle aspiration (FNA). Herein, we characterise the cytomorphological features of four SFTs involving the pancreas by FNA to establish a preoperative diagnostic approach.

Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.

Tumor cells must alter their antioxidant capacity for maximal metastatic potential. Yet the antioxidant adaptations required for ovarian cancer transcoelomic metastasis, which is the passive dissemination of cells in the peritoneal cavity, remain largely unexplored. Somewhat contradicting the need for oxidant scavenging are previous observations that expression of SIRT3, a nutrient stress sensor and regulator of mitochondrial antioxidant defenses, is often suppressed in many primary tumors.

The acute physiological effects of high- and low-velocity resistance exercise in older adults.

The aim of the present study was to determine if workload matched, high-velocity (HVE) and low-velocity (LVE) resistance exercise protocols, elicit differing acute physiological responses in older adults. Ten older adults completed three sets of eight exercises on six separate occasions (three HVE and three LVE sessions). Systolic blood pressure, diastolic blood pressure and blood lactate were measured pre- and post-exercise, heart rate was measured before exercise and following each set of each exercise.

Utilizing Surgical Bootcamps to Teach Core Entrustable Professional Activities to Senior Medical Students.

To promote residency preparedness, the Association of American Medical Colleges defined 13 core entrustable professional activities for entering residency (CEPAERs), which represent tasks that students should be able to perform on day one of residency. At the authors' institution, a four-week surgery boot camp course is offered to senior medical students, which may provide an effective mechanism for teaching the CEPAERs. Nine senior students participating in a surgery boot camp course were subjected to pre- and post-course surveys.

The perceptual responses to high-velocity, low-load and low-velocity, high-load resistance exercise in older adults.

The present study examined exercise affect during volume-load matched, high-velocity, low-load and low-velocity, high-load resistance exercise conditions in older adults. Ten older adults completed three sets of eight exercises on six separate occasions (three high-velocity, low-load and three low-velocity, high-load sessions) in a crossover study design. High-velocity, low-load was performed at 40% of predicted one repetition maximum, and low-velocity, high-load at 80%.

Movement velocity during high- and low-velocity resistance exercise protocols in older adults.

The primary aim of the present study was to determine the actual movement velocity of high-velocity, low-load (HVLL) and low-velocity, high-load (LVHL) resistance exercise in a group of older adults. The secondary aim was to examine the differences in velocities produced between male and females. In a crossover study design, four males (age: 67±3years) and five females (age: 68±2years) completed three sets of leg press, calf raise, leg curl, leg extension, chest press, seated row, bicep curl and tricep extension on six separate occasions (three HVLL and three LVHL sessions).