Genome sequences of three temperate actinobacteriophages from clusters FA and AS.

Three novel temperate siphoviruses, Juno112, KHumphrey, and ChuckDuck, were isolated from soil at Stevenson University using the bacterium B-2979. Based on gene content similarity, Juno112 and KHumphrey are assigned to actinobacteriophage cluster AS3 and ChuckDuck to cluster FA. All three phages encode tyrosine recombinases, with ChuckDuck encoding two.

Differential regulation of functional gene clusters in overt coronary artery disease in a transgenic atherosclerosis-hypertensive rat model.

Background: Human acute coronary syndrome refers to the spectrum of clinical manifestations of overt coronary artery (CAD) disease characterized by atherosclerotic plaque destabilization and resultant myocardial injury. Typically studied as distinct pathologies, emerging pathogenic paradigms implicate multiple processes beyond thrombosis and ischemic cell injury respectively, with significant pathway overlap involving inflammation, apoptosis, matrix degradation, and oxidative stress. However, all these pathways have also been implicated in still-quiescent coronary plaque progression, thus making it harder to pinpoint the turnkey events leading to overt-CAD.