Publications by authors named "Victoria M Defelippe"
Article Synopsis
- N-of-1 trials are single-patient studies that focus on individual responses to treatments, particularly useful for patients with rare forms of epilepsy where larger clinical trials are hard to conduct.
- A systematic review analyzed such trials to evaluate their design, outcomes, and biases, revealing strong individual treatment customization but also some reporting limitations.
- The findings highlight the potential of N-of-1 trials to provide valuable insights for treating epilepsy, suggesting a need for improved reporting and methodology in future studies.
Article Synopsis
- N-of-1 strategies help doctors find out if a treatment works really well for one specific person, especially when they have a rare disease.
- There’s a debate on whether these strategies should follow rules for research or rules for medical care since they mix both.
- The text explains how to set up these strategies safely to choose the best treatments for people with rare diseases.
Nitrous oxide (NO) is an inhalant that has become increasingly popular as a recreational drug. While it is presumed to be harmless, a number of adverse effects of NO have been described. We discuss the case of a 24-year-old man with no medical history, who initially presented to the emergency department with progressive polyneuropathy caused by vitamin B deficiency after NO abuse.
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