Publications by authors named "Victoria M Andrews"
Article Synopsis
- Canonical pre-mRNA splicing typically requires certain proteins (snRNPs) to remove long introns, but non-canonical splicing has been observed for some short introns in tRNAs and mRNAs, like XBP1.
- Researchers in this study developed a method to identify short introns using RNA-Seq data, finding hundreds of conserved short introns across different human cell types that are often alternatively spliced.
- The study reveals that splicing efficiency for these short introns can be enhanced by their secondary structures, and their removal can change the reading frame of mRNAs, indicating that current gene prediction models may not effectively account for these introns in the human transcriptome.
