Publications by authors named "Victoria Laurencin"
Vasopressin (AVP), a nonapeptide synthesized predominantly by magnocellular hypothalamic neurons, is conveyed to the posterior pituitary the pituitary stalk, where AVP is secreted into the circulation. Known to regulate blood pressure and water homeostasis, it also modulates diverse social behaviors, such as pair-bonding, social recognition and cognition in mammals including humans. Importantly, AVP modulates social behaviors in a gender-specific manner, perhaps, due to gender differences in the distribution in the brain of AVP and its main receptor AVPR1a.
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- High levels of follicle-stimulating hormone (FSH) in post-menopausal women are linked to the development of Alzheimer's disease (AD), as shown by studies in mice.
- Mice lacking FSH receptors displayed improved spatial memory, indicating that blocking FSH signaling can help prevent memory loss related to aging and AD-like pathology.
- The findings suggest that targeting FSH could be a potential strategy for preventing memory deficits in post-menopausal women.
Article Synopsis
- The pituitary gland secretes tropic hormones that regulate various endocrine organs and are involved in functions like skeletal modeling, metabolism, and cognitive processes.
- Hormones like FSH, traditionally known for their role in reproductive health, also play significant roles in fat and bone metabolism as well as cognition.
- Research shows that understanding the broader functions of FSH may lead to new therapeutic options for health issues related to menopause, including osteoporosis, obesity, and dementia.
Article Synopsis
- Alzheimer's disease (AD) is linked to high levels of follicle-stimulating hormone (FSH) in post-menopausal women, which may trigger memory loss and AD-like symptoms in mice.
- A study tested different groups of female mice (some unoperated, some with surgery, and some undergoing ovariectomy) and found that gene-deletion of FSH receptor (Fshr) improved spatial memory and recognized memory, highlighting a gene-dose effect.
- Overall, the research suggests that lower FSH levels could have protective benefits against memory loss associated with aging and AD, as indicated by better memory retention in mice with reduced FSH signaling.