Publications by authors named "Victoria Goldsworthy"

RNA aptamers that bind non-fluorescent dyes and activate their fluorescence are highly sensitive, nonperturbing, and convenient probes in the field of synthetic biology. These RNA molecules, referred to as light-up aptamers, operate as molecular nanoswitches that alter folding and fluorescence function in response to ligand binding, which is important in biosensing and molecular computing. Herein, we demonstrate a conceptually new generation of smart RNA nano-devices based on malachite green (MG)-binding RNA aptamer, which fluorescence output controlled by addition of short DNA oligonucleotides inputs.

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Article Synopsis
  • * A set of 16 customizable nanoparticle platforms based on nucleic acids is developed, allowing for controlled self-assembly that can modulate immune responses effectively.
  • * Key properties like molecular weight, melting temperature, and half-life are identified as critical factors predicting the immunomodulatory activity of these nanoparticles, paving the way for designing new, predictable therapeutic tools.
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