A significant proportion of pharmaceuticals are fluorinated and selecting the site of fluorine incorporation can be an important beneficial part a drug development process. Here we describe initial experiments aimed at the development of a general method of selecting optimum sites on pro-drug molecules for fluorination, so that metabolic stability may be improved. Several model biphenyl derivatives were transformed by the fungus Cunninghamella elegans and the bacterium Streptomyces griseus, both of which contain cytochromes P450 that mimic oxidation processes in vivo, so that the site of oxidation could be determined.
View Article and Find Full Text PDFThe dialysis procedure should be individually tailored to the client at all times. Learn each client's signs and symptoms for a hypotensive occurrence as well as other signals that suggest the need to adjust fluid removal when aiming for or establishing a new dry weight. Clients may display a variety of indicators, and it is imperative to familiarize yourself as much as possible with client-specific symptoms.
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