Publications by authors named "Victoria E Thomas"
Racial and Socioeconomic Health Disparities in Peripheral Artery Disease.
J Am Heart Assoc
November 2024
Article Synopsis
- Peripheral artery disease (PAD) is a worsening condition causing narrowing of the arteries in the legs, leading to serious risks like heart attacks and amputations, particularly affecting marginalized racial and ethnic groups in the U.S.
- Despite advances in treatment, outcomes for PAD remain worse for Black, Hispanic, and American Indian populations compared to White individuals, highlighting significant health disparities.
- Research increasingly emphasizes the importance of social determinants of health, rather than biological factors, in understanding these disparities and suggests that improved policies and strategies could promote health equity.
Background: Life's essential 8 (LE8) is a comprehensive construct of cardiovascular health. Yet, little is known about the LE8 score, its metabolic correlates, and their predictive implications among Black Americans and low-income individuals.
Methods: In a nested case-control study of coronary heart disease (CHD) among 299 pairs of Black and 298 pairs of White low-income Americans from the Southern Community Cohort Study, we estimated LE8 score and applied untargeted plasma metabolomics and elastic net with leave-one-out cross-validation to identify metabolite signature (MetaSig) of LE8.
Purpose Of Review: Cardiometabolic diseases (CMDs) are leading causes of death and disproportionally impact historically marginalized racial/ethnic groups in the United States. The American Heart Association developed the Life's Essential 8 (LE8) to promote optimal cardiovascular health (CVH) through eight health behaviors and health factors. The purpose of this review is to summarize contemporary community-engaged research (CER) studies incorporating the LE8 framework among racial/ethnic groups.
View Article and Find Full Text PDFBackground And Aims: Life's Essential 8 (LE8) is a comprehensive construct of cardiovascular health. Yet, little is known about LE8 score, its metabolic correlates, and their predictive implications among Black Americans and low-income individuals.
Methods: In a nested case-control study of coronary heart disease (CHD) among 598 Black and 596 White low-income Americans, we estimated LE8 score, conducted untargeted plasma metabolites profiling, and used elastic net with leave-one-out cross-validation to identify metabolite signature (MetaSig) of LE8.
Amyloidosis: diagnosis and new therapies for a misunderstood and misdiagnosed disease.
Neurodegener Dis Manag
December 2019
Amyloidosis is a group of diseases characterized by extracellular deposition of amyloid fibril complexes. Fibril deposition results in organ dysfunction and possible failure. Amyloidosis is regarded as a rare disease, but in general is underdiagnosed.
View Article and Find Full Text PDF