Gut Microbiome Composition Predicts Infection Risk During Chemotherapy in Children With Acute Lymphoblastic Leukemia.

Background: Myelosuppression-related infections remain important causes of morbidity and mortality in children with acute lymphoblastic leukemia (ALL).

Methods: By analyzing fecal samples collected at diagnosis and after each of the initial 3 phases of chemotherapy, we evaluated the role of gut microbiota in predicting infections in 199 children with newly diagnosed ALL. The bacterial 16S rRNA gene was analyzed by high-depth sequencing to determine the diversity and composition of the microbiome.

Immunological effects and therapeutic role of C5a in cancer.

The specific role of C5a in cancer, especially in melanoma, has yet to be determined. Differential effects of C5a could be cancer specific. In the host defense system, C5a functions to protect the body from harmful entities via a plethora of mechanisms.

Straightforward reductive routes to air-stable uranium(III) and neptunium(III) materials.

Studies of trivalent uranium (U(3+)) and neptunium (Np(3+)) are restricted by the tendency of these ions to oxidize in the presence of air and water, requiring manipulations to be carried out in inert conditions to produce trivalent products. While the organometallic and high-temperature reduction chemistry of U(3+) and, to a much smaller extent, Np(3+) has been explored, the study of the oxoanion chemistry of these species has been limited despite their interesting optical and magnetic properties. We report the synthesis of U(3+) and Np(3+) sulfates by utilizing zinc amalgam as an in situ reductant with absolutely no regard to the exclusion of O2 or water.

A new family of lanthanide borate halides with unusual coordination and a new neodymium-containing cationic framework.

The reactions of Ln(2)O(3)/CeO(2)/Pr(6)O(11) (Ln = La-Nd, Sm), molten boric acid, and concentrated HBr or HI result in the formation of La[B(7)O(10)(OH)(3)(H(2)O)Br], Ln[B(6)O(9)(OH)(2)(H(2)O)(2)Br]·0.5H(2)O (Ln = Ce, Pr), Nd(2)[B(12)O(17.5)(OH)(5)(H(2)O)(4)Br(1.