Memantine-Derived Schiff Bases as Transdermal Prodrug Candidates.

Condensation reactions of salicylaldehyde, 2-pyridinecarboxaldehyde, and pyridoxaldehyde with memantine () produced novel memantine-derived Schiff bases (-). Speciation predictions and calculations of Log P, Log D, and of the percentage (%) of neutral species for (-) were carried out. In comparison with , the Schiff bases presented increased log P and log D in all cases and pH values, suggesting higher hydrophobicity.