Publications by authors named "Victoria Alvarez Sanchez"
Screening uptake of colonoscopy versus fecal immunochemical testing in first-degree relatives of patients with non-syndromic colorectal cancer: A multicenter, open-label, parallel-group, randomized trial (ParCoFit study).
PLoS Med
October 2023
Article Synopsis
- A study was done to see if a type of screening test called FIT was better than the usual procedure, colonoscopy, for first-degree relatives of people with colorectal cancer.
- The researchers wanted to know if more people would agree to take the FIT test compared to colonoscopy and if both tests would find the same number of serious issues.
- The study was planned to involve many people over several years but had to stop early because it wasn't looking like it would have good results, even though they still gathered data for two years after.
We aimed to assess the risk of cancer in patients with abdominal symptoms after a complete colonoscopy without colorectal cancer (CRC), according to the carcinoembryonic antigen (CEA) concentration, as well as its diagnostic accuracy. For this purpose, we performed a post-hoc analysis within a cohort of 1431 patients from the COLONPREDICT study, prospectively designed to assess the fecal immunochemical test accuracy in detecting CRC. Over 36.
View Article and Find Full Text PDFBackground: Faecal immunochemical test (FIT) has been recommended to assess symptomatic patients for colorectal cancer (CRC) detection. Nevertheless, some conditions could theoretically favour blood originating in proximal areas of the gastrointestinal tract passing through the colon unmetabolized. A positive FIT result could be related to other gastrointestinal cancers (GIC).
View Article and Find Full Text PDFEffect of aspirin on the diagnostic accuracy of the faecal immunochemical test for colorectal advanced neoplasia.
United European Gastroenterol J
February 2018
Background: Aspirin (ASA) is a drug that can cause gastrointestinal lesions and symptoms. Colorectal cancer (CRC) is the most prevalent type of cancer in Western countries. We assessed the effect of aspirin on the diagnostic accuracy of the faecal immunochemical test (FIT) for CRC and/or advanced neoplasia (AN) in patients undergoing colonoscopy for gastrointestinal symptoms.
View Article and Find Full Text PDFArticle Synopsis
- Researchers created the FAST Score, a prediction model for colorectal cancer (CRC) that uses simple factors like fecal haemoglobin concentration, age, and sex to enhance diagnosis in symptomatic patients.
- The model was validated through extensive studies involving over 5,500 patients, showing strong diagnostic accuracy with an AUC of 0.88 in the initial group and 0.91 in the validation group.
- The FAST Score effectively categorizes patients into high, intermediate, and low-risk groups for CRC, making it a practical tool for clinicians in assessing symptoms and prioritizing colonoscopy referrals.
Article Synopsis
- This study developed and validated a colorectal cancer (CRC) prediction model called COLONPREDICT, using clinical and laboratory data from patients with gastrointestinal symptoms referred for colonoscopy.
- The model included 11 key variables, including age, gender, and specific test results, achieving a diagnostic accuracy with an area under the curve (AUC) of 0.92.
- COLONPREDICT outperformed the existing NICE referral criteria, which had a significantly lower AUC of 0.59, indicating it may be a better tool for CRC detection.
Background: Pancreatitis is the most feared complication of endoscopic papillectomy (EP). Prevention by pancreatic duct stenting following EP has been advocated but not proven by a randomized trial. The purpose of the present retrospective review is to compare a period of systematic stenting with the period before in which stents were placed selectively.
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