Publications by authors named "Victoria A Fisher"
Article Synopsis
- - A study estimates that 20% of men in the UK have detectable loss of chromosome Y (LOY) in their white blood cells, a common genetic phenomenon.
- - Researchers identified 156 genes associated with LOY, linking them to cell-cycle regulation, cancer risk, and tumor growth, affirming LOY's relevance to health issues beyond blood disorders.
- - The findings suggest that LOY may indicate genomic instability in other tissues and emphasize the importance of understanding clonal mosaicism for insights into cancer and age-related diseases. !*
Background: Genome wide-association studies have successfully identified several hundred independent loci harboring common cancer susceptibility alleles that are distinct from the more than 110 cancer predisposition genes. The latter are generally characterized by disruptive mutations in coding genes that have been established as 'drivers' of cancer in large somatic sequencing studies. We set out to determine whether, similarly, common cancer susceptibility loci map to genes that have altered frequencies of mutation.
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