Deadly Sphenoid Fungus-Isolated Sphenoid Invasive Fungal Rhinosinusitis: A Case Report.

Introduction: Acute invasive fungal rhinosinusitis (AIFRS) is a potentially fatal infection, usually affecting immunocompromised patients. Isolated sphenoid sinus involvement is rare and has been reported in only a few cases. We discuss the clinical characteristics, histopathologic features, and differential diagnosis of AIFRS of the sphenoid sinus.

In vivo determination of mouse olfactory mucus cation concentrations in normal and inflammatory states.

Objective: Olfaction is impaired in chronic rhinosinusitis (CRS). The study has two aims: (1) to determine whether changes in cation concentration occur in the olfactory mucus of mice with CRS, which may affect chemo-electrical transduction, (2) and to examine whether these alterations are physiologically significant in humans.

Study Design: Animal study in mice and translational study in humans.

Prevalence of depression and antidepressant use in an otolaryngology patient population.

Objective: To determine the prevalence of depressive diagnoses and antidepressant use in various subsets of otolaryngology patients.

Study Design: Academic practice EMR database query.

Subjects And Methods: Over 12,000 consecutive otolaryngology patients were analyzed by primary diagnosis and in three groups: Group 1 (tinnitus, vertigo), Group 2 (rhinosinusitis), and Group 3 (sleep apnea).

Invasive fungal sinusitis and complications of rhinosinusitis.

Acute fulminant invasive fungal sinusitis in an immunocompromised host and bacterial rhinosinusitis with intracranial or orbital extension are challenging to manage and constitute true otolaryngic emergencies. In the absence of rapid diagnosis and treatment, these diseases can be fatal. In this article, the complications of bacterial rhinosinusitis are divided into three categories: local, orbital, and intracranial.

Intranasal Aspergillus fumigatus exposure induces eosinophilic inflammation and olfactory sensory neuron cell death in mice.

Objective: To determine the effects of eosinophilic inflammation on olfactory sensory neuron cell death.

Study Design: Mice were sensitized to intranasal Aspergillus fumigatus extract and subsequently challenged acutely or chronically with the same allergen. The olfactory neuroepithelium was assessed for immunohistochemical evidence of apoptosis and inflammation.