Publications by authors named "Victoria A Cornelius"
Article Synopsis
- Vascular organoids (VOs) from induced pluripotent stem cells (iPSCs) show promise as models for studying human vascular diseases and drug testing, but their effectiveness in mimicking actual human conditions needs further exploration.
- DB-VOs derived from diabetic patients were found to have impaired function compared to non-diabetic counterparts, displaying harmful traits such as high reactive oxygen
Article Synopsis
- Cardiovascular diseases are a major cause of death and impact quality of life, necessitating effective treatments like endovascular procedures and vascular grafts for long-term care.
- Innovative 3D printing techniques have been utilized to create biodegradable vascular grafts loaded with clopidogrel (CLOP), enhancing their mechanical and biological properties while allowing for customization.
- Test results show these 3D-printed grafts offer sustained drug release, reduced platelet deposition, low hemolysis, and promote cell attachment and growth, indicating their potential for improved vascular treatments.
Article Synopsis
- Understanding cardiovascular risk factors like diabetes in vascular cells is challenging due to limited disease models.
- The review discusses the development of advanced 3D in vitro disease models using patient-derived stem cells, which better mimic human vascular issues compared to traditional 2D cultures.
- It highlights the importance of including various cell types in these models to accurately represent conditions like diabetic vasculopathy and suggests strategies for creating organ-specific models to study different vascular complications.
Article Synopsis
- Vascular complications are the leading cause of health issues and death related to diabetes, stemming from oxidative stress and metabolic problems.
- Mitochondrial dysfunction significantly contributes to issues in heart function and energy metabolism in diabetes, with non-coding RNAs and RNA-binding proteins potentially playing a role, though their specific impacts remain unclear.
- Using stem cell-based models can help researchers explore the relationship between non-coding RNAs, RNA-binding proteins, and mitochondrial dysfunction, which may lead to better treatments for diabetic vascular complications.
Article Synopsis
- Vascular diseases are a major global health issue, with cardiovascular diseases being the top cause of death, highlighting the urgent need for effective treatments.
- Recent advances in regenerative medicine, especially through induced pluripotent stem cell (iPSC) technologies, have enhanced understanding of the vascular system and its cellular components, paving the way for new therapeutic strategies.
- The study of RNA-binding proteins (RBPs) using iPSC models reveals their critical role in regulating gene expression and cellular functions, providing insights into vascular dysfunction and opportunities for novel treatments, particularly focusing on the Quaking family of isoforms.
Implantable drug delivery systems are an interesting alternative to conventional drug delivery systems to achieve local or systemic drug delivery. In this work, we investigated the potential of fused-deposition modelling to prepare reservoir-type implantable devices for sustained drug delivery. An antibiotic was chosen as a model molecule to evaluate the potential of this type of technology to prepare implants on-demand to provide prophylactic antimicrobial treatment after surgery.
View Article and Find Full Text PDFDevelopment of drug loaded cardiovascular prosthesis for thrombosis prevention using 3D printing.
Mater Sci Eng C Mater Biol Appl
October 2021
Cardiovascular disease (CVD) is a general term for conditions which are the leading cause of death in the world. Quick restoration of tissue perfusion is a key factor to combat these diseases and improve the quality and duration of patients' life. Revascularization techniques include angioplasty, placement of a stent, or surgical bypass grafting.
View Article and Find Full Text PDFArticle Synopsis
- Cardiovascular disease is the leading cause of death in people with diabetes, primarily due to atherosclerosis and related vascular complications.
- Research highlights how diabetes disrupts the endothelium (the inner lining of blood vessels), but the exact mechanisms behind this dysfunction are not fully understood.
- The review examines the significance of alternative splicing in gene expression related to vascular health, focusing on how mis-splicing contributes to diseases like atherosclerosis and discussing potential therapies to correct these splicing errors.
RNA-binding proteins (RBPs) are multi-faceted proteins in the regulation of RNA or its RNA splicing, localisation, stability, and translation. Amassing proof from many recent and dedicated studies reinforces the perception of RBPs exerting control through differing expression levels, cellular localization and post-transcriptional alterations. However, since the regulation of RBPs is reliant on the micro-environment and events like stress response and metabolism, their binding affinities and the resulting RNA-RBP networks may be affected.
View Article and Find Full Text PDFCardiovascular diseases constitute a number of conditions which are the leading cause of death globally. To combat these diseases and improve the quality and duration of life, several cardiac implants have been developed, including stents, vascular grafts and valvular prostheses. The implantation of these vascular prosthesis has associated risks such as infection or blood clot formation.
View Article and Find Full Text PDFDiabetic endotheliopathy: RNA-binding proteins as new therapeutic targets.
Int J Biochem Cell Biol
February 2021
Diabetic Endotheliopathy is widely regarded as a principal contributor to cardiovascular disease pathogenesis in individuals with Diabetes mellitus. The endothelium, the innermost lining of blood vessels, consists of an extensive monolayer of endothelial cells. Previously regarded as an interface, the endothelium is now accepted as an organ system with critical roles in vascular health; its dysfunction therefore is detrimental.
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