Striatal response to negative feedback in a stop signal task operates as a multi-value learning signal.

Background And Aim: We examined error-driven learning in fMRI activity of 217 subjects in a stop signal task to obtain a more robust characterization of the relation between behavioral measures of learning and corresponding neural learning signals than previously possible.

Methods: The stop signal task is a two-alternative forced choice in which participants respond to an arrow by pressing a left or right button but must inhibit that response on 1 in 7 trials when cued by an auditory "stop signal." We examined post-error learning by comparing brain activity (BOLD signal) and behavioral responses on trials preceded by successful (correct stop) vs.