Publications by authors named "Victor Volkomorov"
Research Question: Do clinical and neonatal outcomes differ between mosaic embryo transfers (MET) and euploid embryo transfers (EET)?
Design: This retrospective cohort study compared the implantation rate, live birth rate (LBR) and miscarriage rate between 513 euploid embryos and 118 mosaic embryos (72 whole chromosome mosaic [WCM], 40 segmental mosaic and six complex mosaic). Blastocysts were analysed using preimplantation genetic testing for aneuploidies with next-generation sequencing, followed by a single vitrified-warmed embryo transfer. Trophectoderm biopsies were classified as mosaic if they had 20-80% abnormal cells.
Article Synopsis
- The study aimed to investigate the changes in multidrug resistance (MDR) gene expression in stage IIA-IIIC breast cancer patients before and after receiving neoadjuvant chemotherapy (NAC).
- All patients underwent different chemotherapy regimens, and researchers measured key MDR gene expressions in tumor samples taken before and after treatment to determine any correlations with treatment response.
- Results indicated that reduced MDR gene expression post-chemotherapy was linked to a positive tumor response, while increased expression was associated with treatment resistance, highlighting the potential of MDR gene levels as predictors for chemotherapy effectiveness.
Background: Transforming growth factor β1 (TGF-β1) is a multifunctional cytokine that plays an important role in human mammary carcinogenesis. The purpose of this study was to investigate the association between -509C>T single nucleotide polymorphism (SNP) of the TGF-β1 gene and infiltrating ductal breast carcinoma risk in Russian patients of Western Siberian region.
Materials And Methods: Blood samples collected from 218 women with histologically confirmed infiltrating ductal breast carcinoma and 290 healthy female controls were analyzed through polymerase chain reaction-restriction fragment length polymorphism methods.