Publications by authors named "Victor V Samsonov"
Article Synopsis
- L-serine biosynthesis starts with D-3-phosphoglycerate being converted into 3-phosphohydroxypyruvate by the enzyme SerA, which can also produce D-2-hydroxyglutarate (D-2-HGA) from 2-ketoglutarate.
- Recent discoveries have identified bacterial enzymes called D2HGDHs that convert D-2-HGA back to 2-ketoglutarate; however, little is known about these enzymes in certain bacterial families.
- Two novel D2HGDHs were characterized, revealing their substrate specificity, optimal pH conditions, and sensitivity to metal ions, suggesting their potential use in metabolic engineering for creating microbes with specific traits.
We had previously shown that the Escherichia coli proteins DcrA (SdaC) and DcrB, located, respectively, in the inner membrane and periplasm, are involved in the early development of virulent bacteriophage C1, which recognises BtuB as an outer membrane receptor. In the present work it is demonstrated that the DcrA and DcrB proteins, coordinately with another outer membrane receptor protein, FhuA, are also involved in an early stage of development of a newly isolated virulent phage, C6. In both cases, DcrA and DcrB probably are required in the second stage of phage adsorption-the DNA injection process.
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