Patch and matrix striatonigral neurons differentially regulate locomotion.

The striatonigral neurons are known to promote locomotion. These neurons reside in both the patch (also known as striosome) and matrix compartments of the dorsal striatum. However, the specific contribution of patch and matrix striatonigral neurons to locomotion remain largely unexplored.

Dilemmas in parenteral glucose delivery and approach to glucose monitoring and interpretation in the neonate.

Glucose control continues to be challenging for intensivists, in particular in high-risk neonates. Many factors play a role in glucose regulation including intrinsic and extrinsic factors. Optimal targets for euglycemia are debatable with uncertain short and long-term effects.

General practice training environment and its impact on preparedness.

Introduction: The notion of preparedness for practice is poorly defined in medical education literature. It is unclear what preparedness means and how the training environment impacts on preparedness for practice.

Objectives: This paper aims to explore the meaning that GP trainees and newly qualified GPs attach to the notion of preparedness, and to examine the ways in which they perceive their training environment to impact on preparedness.

Describing the learning climate of general practice training: the learner's perspective.

The learning climate is an important aspect of educational environments that impacts on learner satisfaction, stress and attitudes to learning. Quality management of educational environments has traditionally focused on teacher development and aspects of the environment that are easily quantifiable. This study describes the learning climate of GP training practices from the perspective of the learners.

Sudden cardiac death in young children with neurofibromatosis type 1.

Patients with neurofibromatosis type 1 (NF1) can manifest a characteristic vasculopathy that in adults is rarely associated with fatal coronary artery occlusion. We describe the clinical and pathological findings from 2 unrelated young children with NF1, a similar vasculopathy affecting their coronary arteries, and sudden cardiac death.

Mapping of neurokinin-like immunoreactivity in the human brainstem.

Background: Using an indirect immunoperoxidase technique, we have studied the distribution of immunoreactive fibers and cell bodies containing neurokinin in the adult human brainstem with no prior history of neurological or psychiatric disease.

Results: Clusters of immunoreactive cell bodies and high densities of neurokinin-immunoreactive fibers were located in the periaqueductal gray, the dorsal motor nucleus of the vagus and in the reticular formation of the medulla, pons and mesencephalon. Moreover, immunoreactive cell bodies were found in the inferior colliculus, the raphe obscurus, the nucleus prepositus hypoglossi, and in the midline of the anterior medulla oblongata.