Composite Based on Biphasic Calcium Phosphate (HA/β-TCP) and Nanocellulose from the Açaí Tegument.

The use of lignocellulosic remnants of the açaí agro-business will benefit the environment with a precursor material for biomedical applications. Nanocellulose (NC) allows the biomimetic growth of biphasic ceramics on its surface, with characteristics compatible with bone tissue, including bioactive properties and biocompatibility. In this study, the composites were obtained from açaí tegument ( Mart.

Biosynthesis, characterization and leishmanicidal activity of a biocomposite containing AgNPs-PVP-glucantime.

Aim: Development of functionalized nanocomposites containing AgNPs-PVP-Glucantime to evaluate their leishmanicidal activity as a novel method for improving the pharmacological properties of the drug Glucantime against extracellular promastigotes and intracellular amastigotes of Leishmania amazonensis in vitro to treat cutaneous leishmaniasis.

Materials & Methods: The silver nanoparticles and nanocomposites prepared containing silver nanoparticles, polyvinylpyrrolidone and different amounts of Glucantime were characterized using transmission electron microscopy, x-ray diffraction, energy-dispersive x-ray spectroscopy and ζ potential analysis; in addition, the in vitro cytotoxicity was evaluated.

Results: The nanocomposites showed an inhibitory effect on the cellular viability of promastigote forms, with values of 47.