Publications by authors named "Victor Proenca Ricardo"
The aim of the present study was to investigate the effects of 17beta-estradiol on expression of muscarinic acetylcholine receptor subtypes (M1 to M5) and estrogen receptor alpha, in the rat hippocampus. Hippocampi were obtained from rats in proestrus, rats ovariectomized for 15 days, rats ovariectomized for 15 days and then treated with 17beta-estradiol for 7 days, and rats ovariectomized and immediately treated with 17beta-estradiol for 21 days. Expression of M1 to M5 was increased in hippocampi of rats ovariectomized for 15 days compared to rats in proestrus.
View Article and Find Full Text PDFOne important contributing factor in the high prevalence of drug abuse disorders seen among schizophrenic patients seems to be related to chronic treatment with typical neuroleptics. We have previously demonstrated that withdrawal from long-term treatment with the typical neuroleptic haloperidol, but not the atypical neuroleptic ziprasidone, potentiated the hyperlocomotor effect induced by a single cocaine injection and cocaine-induced conditioned place preference in mice. In the present study we investigated whether withdrawal from long-term treatment with these same neuroleptics would also modify cocaine-induced hyperlocomotion sensitization, which has been proposed as an animal model for the intensification of drug craving in cocaine addiction.
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- The study evaluated how social isolation versus crowding affects female mice's behavior after they received single or repeated doses of ethanol.
- While single ethanol doses increased movement regardless of housing conditions, repeated doses caused greater sensitivity in crowded mice compared to those isolated or in control conditions.
- Social isolation reduced the negative impact of ethanol on behavior (like increased immobility) and promoted tolerance to some effects, indicating that living conditions significantly influence how ethanol affects behavior.