Engineered PROTAC-CID Systems for Mammalian Inducible Gene Regulation.

Gene regulation via chemically induced dimerization (CID) is useful for biomedical research. However, the number, type, versatility, and in vivo applications of CID tools remain limited. Here, we demonstrate the development of proteolysis-targeting chimera-based scalable CID (PROTAC-CID) platforms by systematically engineering the available PROTAC systems for inducible gene regulation and gene editing.

Dental treatment under general anesthesia in patients with severe intellectual disability at the Gregorio Marañón General University Hospital: a 10-year retrospective study.

Objectives: There is a high demand for dental treatment in a hospital setting for patients with severe intellectual disability (ID), due to their inability to cooperate. The objective was to determine the types of dental treatment carried out on patients with severe ID, as well as the possibility of performing clinical and radiographic examinations prior to treatment and to identify their characteristics.

Method And Materials: A retrospective observational study was performed, based on the medical histories of patients with severe ID or a disability included in the portfolio of dental services of Community of Madrid, who underwent dental treatment at the Stomatology Service of the Gregorio Marañón General University Hospital from the year 2009 to 2019.

Under-exposure to official matches is associated with muscle injury incidence in professional footballers.

External workload from matches is considered one of the most important muscle injury risk factors for football teams. However, there is scarce published evidence to support this belief. This study examined whether a particular profile of external match workload existed prior to a muscle injury.

Effects of muscular injuries on the technical and physical performance of professional soccer players.

: The aim of this study was to determine the effects of muscular injuries in the lower limbs on the technical and physical performance of professional soccer players when they return to the league competition. : Seventy-six muscular injuries incurred by Spanish male professional soccer players (Age: 27.5 ± 3.

Implant treatment in immunosuppressed renal transplant patients: A prospective case-controlled study.

Objectives: The aim of this clinical study was to evaluate long-term outcomes of implant therapy in a cohort of immunosuppressed renal transplant patients compared with a matched control group.

Material And Methods: Pharmacologically immunosuppressed renal transplant patients received dental implant treatment between 2001 and 2011. Periodontal, clinical and radiographic parameters were prospectively measured with a mean follow-up of 116.

Neurodynamic mobilization and foam rolling improved delayed-onset muscle soreness in a healthy adult population: a randomized controlled clinical trial.

Objectives: Compare the immediate effects of a Neurodynamic Mobilization (NM) treatment or foam roller (FR) treatment after DOMS.

Design: Double blind randomised clinical trial.

Setting: The participants performed 100 drop jumps (5 sets of 20 repetitions, separated by 2 min rests) from a 0.

Implant treatment in pharmacologically immunosuppressed liver transplant patients: A prospective-controlled study.

Objectives: The main objective of this prospective study was to evaluate the long-term outcome of implant therapy in liver transplant patients (LTP). The secondary goal was to assess several implant- and patient-dependent variables, such as peri-implantitis (PI), peri-implant mucositis (PIM), bone loss (BL), and immediate postoperative complications.

Material And Methods: Two groups, including 16 pharmacologically immunosuppressed LTP and 16 matched controls, received 52 and 54 implants, respectively, between 1999 and 2008.

Prevalence of multiple sclerosis in Latin America and its relationship with European migration.

Multiple sclerosis (MS) is a chronic, degenerative autoimmune inflammatory disease of the central nervous system. The prevalence is different in every continent, changing according to geographical and environmental characteristics. The areas with the highest prevalence in the world are Europe and North America.

Surgical Treatment of a Peripheral Ossifying Fibroma and Reconstruction with a Porcine Collagen Matrix: A Case Report.

A 35-year-old woman was referred to the Department of Oral Medicine and Orofacial Surgery after several recurrences of an ossifying fibroma (OF) that affected the free and attached gingiva of the maxillary right central incisor. Surgery was performed with a complete excision of the lesion together with the surrounding healthy tissue up to the bone. To guide the healing of the anterior esthetic framework and the excised tissues, a porcine collagen matrix as an alternative to connective tissue graft was used.

Prevalence of Oral Mucosal Disorders in Diabetes Mellitus Patients Compared with a Control Group.

Chronic hyperglycemia is associated with impaired wound healing and higher susceptibility to infections. It is unclear whether patients with diabetes mellitus (DM) present more oral mucosal disorders compared to control groups. The objectives were to compare (a) the prevalence rates of oral mucosal disorders in the DM and non-DM population and (b) the prevalence rates of specific disorders in the DM and non-DM population.

Successful treatment of oral pemphigus vulgaris in an insulin-dependant geriatric patient.

Objective: To present a clinical report of a patient treated with corticosteroids for oral pemphigus vulgaris (PV) lesions.

Background: PV is the type of pemphigus that most often affects the oral mucosa and tends not to appear in elderly people.

Methods: Two biopsies were needed for diagnosis.

Physical Demands of Top-Class Soccer Friendly Matches in Relation to a Playing Position Using Global Positioning System Technology.

The aim of this study was to examine the physical demands imposed on professional soccer players during 11-a-side friendly matches in relation to their playing position, using global positioning system (GPS) technology. One hundred and eleven match performances of a Spanish "La Liga" team during the 2010-11 and 2011-12 pre-seasons were selected for analysis. The activities of the players were monitored using GPS technology with a sampling frequency of 1 Hz.