Chin-up-induced bilateral anterior shoulder dislocation: a case report.

Background: Simultaneous bilateral shoulder dislocations are extremely rare occurrences.

Objective: We present an unusual case where the patient suffered simultaneous bilateral anterior shoulder dislocations during chin-up exercises. To our knowledge, this mechanism has not been previously reported.

A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site.

We identified UIC-94003, a nonpeptidic human immunodeficiency virus (HIV) protease inhibitor (PI), containing 3(R),3a(S),6a(R)-bis-tetrahydrofuranyl urethane (bis-THF) and a sulfonamide isostere, which is extremely potent against a wide spectrum of HIV (50% inhibitory concentration, 0.0003 to 0.0005 microM).