Publications by authors named "Victor Manuel Castellano Megias"
Tissue biopsy remains the standard for diagnosing gastrointestinal stromal tumors (GISTs), although liquid biopsy is emerging as a promising alternative in oncology. In this pilot study, we advocate for droplet digital PCR (ddPCR) to diagnose GIST in tissue samples and explore its potential for early diagnosis via liquid biopsy, focusing on the D842V mutation and hypermethylated gene. We utilized ddPCR to analyze the predominant mutation (D842V) in surgical tissue samples from 15 GIST patients, correlating with pathologists' diagnoses.
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- Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is a newly recognized condition linked to Epstein-Barr virus and often arises in immunosuppressed patients, primarily affecting the oropharynx or skin, though rare cases occur in the colon.
- A 31-year-old man with ulcerative proctitis treated with azathioprine and adalimumab experienced a suspected flare-up, leading to hospital admission where he showed severe endoscopic activity but no infection was found.
- After starting intravenous steroids, his condition improved and he was discharged; subsequent histological analysis confirmed EBVMCU, leading to the discontinuation of his immunosuppressants while continuing steroid treatment and mesalazine with
Lanthanum carbonate is a non-calcium phosphorus chelator used in the treatment of hyperphosphatemia associated with chronic renal disease. Deposits of lanthanum in the gastrointestinal wall have been recently described but its clinical significance is uncertain. We present a case of a 62-year-old male with chronic renal disease treated with lanthanum carbonate for 3 years, with deposits in his gastric mucosa, found on biopsy for dyspepsia.
View Article and Find Full Text PDFBackground: Paget's disease of the vulva (PDV) is a rare entity, with only a few cytologic descriptions having been published on it. Diagnosis is usually delayed because it is often clinically mistaken for some types of dermatosis, and biopsy is usually postponed.
Case: A 56-year-old woman presented with a pruritic, erythematous and ulcerated superficial lesion on the right labium majus of approximately eight months' duration.