Publications by authors named "Victor Laigle"
Sleep intensity is adjusted by the length of previous awake time, and under tight homeostatic control by protein phosphorylation. Here, we establish microglia as a new cellular component of the sleep homeostasis circuit. Using quantitative phosphoproteomics of the mouse frontal cortex, we demonstrate that microglia-specific deletion of TNFα perturbs thousands of phosphorylation sites during the sleep period.
View Article and Find Full Text PDFExtracellular Matrix Derived From Dental Pulp Stem Cells Promotes Mineralization.
Front Bioeng Biotechnol
January 2022
Article Synopsis
- The extracellular matrix (ECM) is crucial for physiological functions, varying by tissue type and influencing cell behavior, particularly in dental pulp stem cells (DPSCs).
- This study focused on identifying ECM proteins from DPSCs and their effects on mineralization in human gingival fibroblasts (GF), which typically don't mineralize on their own.
- Results showed that ECM from both normal and osteogenic conditions allowed GF to attach and grow, with osteogenic ECM promoting greater mineralization, indicating potential applications for tissue engineering in bone-related therapies.
RNF111/Arkadia is an E3 ubiquitin ligase that activates the transforming growth factor-β (TGF-β) pathway by degrading transcriptional repressors SKIL/SnoN and SKI. Truncations of the RING C-terminal domain of RNF111 that abolish its E3 function and subsequently activate TGF-β signaling are observed in some cancers. In the present study, we sought to perform a comprehensive analysis of RNF111 endogenous substrates upon TGF-β signaling activation using an integrative proteomic approach.
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