Non-interacting, Non-opioid, and Non-barbiturate Containing Acute Medication Combinations in Headache: A Pilot Combinatorics Approach Based on DrugBank Database.

Polypharmacy in abortive medications is often inevitable for patients with refractory headaches. We seek to enumerate an exhaustive list of headaches abortive medications that are without drug-drug interactions. We updated a list of acute medications based on the widely used Jefferson Headache Manual with novel abortive medications including ubrogepant, lasmiditan, and rimegepant.