Phase Ib Safety, Two-Dose Study of MultiGeneAngio in Patients with Chronic Critical Limb Ischemia.

Critical limb ischemia (CLI) is the most severe presentation of peripheral arterial disease. We developed cell-based therapy entailing intra-arterial injection of autologous venous endothelial cells (ECs) modified to express angiopoietin 1, combined with autologous venous smooth muscle cells (SMCs) modified to express vascular endothelial growth factor. This combination promoted arteriogenesis in animal models and was safe in patients with limiting claudication.

[Endovascular stent-graft repair of aorto-esophageal fistula causing upper gastrointestinal bleeding].

An 83 year old woman with massive upper GIT bleeding was diagnosed as having an aorto-esophageal fistula in the mid descending thoracic aorta which was mildly aneurysmatic and showed atheromatous changes. Past medical history reported Giant Cell Arteritis. Following endoscopy and evaluation using CT angiography, the patient underwent an endovascular stent graft repair of the thoracic aorta using a Talent stent graft.