Epidemiology, clinical features and outcomes of incident tuberculosis in children in Canada in 2013-2016: results of a national surveillance study.

Purpose: Childhood tuberculosis disease is difficult to diagnose and manage and is an under-recognised cause of morbidity and mortality. Reported data from Canada do not focus on childhood tuberculosis or capture key epidemiologic, clinical and microbiologic details. The purpose of this study was to assess demographics, presentation and clinical features of childhood tuberculosis in Canada.

Stochastic agent-based modeling of tuberculosis in Canadian Indigenous communities.

Background: In Canada, active tuberculosis (TB) disease rates remain disproportionately higher among the Indigenous population, especially among the Inuit in the north. We used mathematical modeling to evaluate how interventions might enhance existing TB control efforts in a region of Nunavut.

Methods: We developed a stochastic, agent-based model of TB transmission that captured the unique household and community structure.

Multidrug and extensively drug-resistant tuberculosis in Canada 1997-2008: demographic and disease characteristics.

Setting: Nationwide Canadian public health surveillance.

Objective: Description of demographic features and disease characteristics of drug-resistant tuberculosis (TB) in Canada over a 12 year period.

Design: Continuous surveillance of all cases of culture-confirmed TB in Canada.

Outcomes of second-line chemotherapy in patients with relapsed extensive small cell lung cancer.

Introduction: Extensive-disease small cell lung cancer (ED SCLC) is characterized by initial chemosensitivity, followed inevitably by relapse. The optimal role of additional chemotherapy at the time of progression is controversial. We reviewed the experience of all patients over a 5-year period with ED SCLC to describe outcomes of second-line chemotherapy.

Mature results of the Ottawa phase II study of intermittent androgen-suppression therapy in prostate cancer: clinical predictors of outcome.

Purpose: To present the mature experience of a phase II trial of intermittent androgen suppression (IAS).

Methods And Materials: Intermittent androgen-suppression therapy was initiated in prostate-cancer patients to delay hormone resistance and minimize potential side effects of androgen-deprivation therapy (ADT). Patients received cyclical periods of ADT and observation (off-treatment interval [OTI]).

Smoking is associated with worse outcomes in patients with prostate cancer treated by radical radiotherapy.

Objective: To investigate the effect of smoking on the outcome in a cohort of men treated for localized prostate cancer at one institution with a uniform protocol of radical external beam radiotherapy (EBRT).

Patients And Methods: The study was a retrospective review of 434 patients with cT1-T4 N0m0 prostate cancer treated with curative intent with EBRT (66 Gy in 33 fractions) between 1990 and 1999. Univariate and multivariate Cox regression analyses were used to estimate the risk associated with smoking on biochemical failure (American Society for Therapeutic Radiology and Oncology definition), local failure, distant failure, overall and disease-specific survival.

Treatment of stage I seminoma: a 15-year review.

Purpose: To review the treatment and outcomes in patients with stage I seminoma after orchidectomy.

Methods: A retrospective chart review of all patients with stage I seminoma referred for initial treatment during the last 15 years was performed. Initial treatment approaches and outcomes were analyzed.

Effective palliative radiotherapy for symptomatic recurrent or residual ovarian cancer.

Objective: To evaluate the efficacy of radiotherapy (RT) for symptomatic recurrent or residual ovarian cancer.

Methods: A review was conducted on patients (pts) treated with palliative RT for symptomatic ovarian cancer at The Ottawa Hospital Regional Cancer Centre between 1990 and 2003. Patient demographics, tumor factors, treatment variables, and clinical outcome were entered into a database.