Publications by authors named "Victor Dayan"

The structural and functional integrity of conduits used for coronary artery bypass grafting is critical for graft patency. Disruption of endothelial integrity and endothelial dysfunction are incurred during conduit harvesting subsequent to mechanical or thermal injury and during conduit storage prior to grafting, leading to acute thrombosis and early graft failure. Late graft failure, in particular that of vein grafts, is precipitated by progressive atherogenesis.

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Objective: The best aortic prosthesis type in 60-70 year old patients is not established. Our aim was to evaluate the survival in a National cohort of patients between 60-70 years old who required surgical aortic valve replacement for aortic stenosis (SAVR) with either a mechanical (MP) or bioprosthesis (BP) valve.

Methods: This is a retrospective study using national data from the Ministry of Health.

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Article Synopsis
  • - The integrity of conduits for coronary artery bypass grafting is crucial for their long-term success, as damage during harvesting and storage can lead to graft failure or thrombosis.
  • - Effective intra-operative management involves choosing the right techniques for harvesting and protecting the conduits, as well as using vasodilators to prevent vasospasm.
  • - Post-operative care includes continuing vasodilator therapy and using medications to prevent atherosclerosis progression, with the review highlighting both established practices and areas needing further study.
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  • Cardiovascular diseases are a big problem around the world, and clinical trials help find better treatments for them.
  • Conflicts of interest (COIs), which can happen when companies have a say in research, can affect how trials are carried out and the results they show.
  • It's important to be careful about COIs in studies because they can change guidelines that doctors follow, and sharing rules and being open about research can help keep everyone’s trust in the science.
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  • The DANAMI-3 DEFER study shows that postponing stent implantation in ST-elevation myocardial infarction (STEMI) is safe and may work well when carefully choosing patients.
  • The study included 198 patients undergoing primary percutaneous coronary intervention (PCI) and compared those who had deferred stenting with those who received immediate stenting.
  • Results indicated that while the deferred stenting group had lower rates of stent use and employed more thrombus aspiration, there were no significant differences in mortality or major adverse events between the two groups, suggesting the need for further research on tailored treatment strategies.
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Background: Prevalence of bioprosthetic valve degeneration (BVD) is rising as the use of bioprosthetic aortic valves increases. Detecting early signs of BVD remains a challenge, with conventional imaging methods often failing to identify early deterioration stages. 18F-fuoride positron emission tomography (PET-CT) is an emerging technique that offers promising prospects to detect subclinical BVD.

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Background: Most evidence for anticoagulation in aortic bioprosthesis is centered on embolic events, bleeding and re-intervention risk. The effect of anticoagulation on hemodynamics has not been previously assessed. Our hypothesis was that patients with anticoagulation (AC) early after aortic valve replacement (AVR) with porcine bioprosthesis have better hemodynamics at 3 years of follow-up.

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Composite end points are common primary outcomes in clinical trials. Their main benefit of utilizing a composite outcome is increasing the number of primary outcome events, meaning fewer participants are required to deliver an adequately powered trial. By combining multiple important end points in the primary outcome rather than having to select only 1, composite end points potentially make clinically meaningful benefits easier to detect and avoid ranking outcomes hierarchically.

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Objectives: The ISCHEMIA trial is a landmark study that has been the subject of heated debate within the cardiovascular community. In this analysis of the ISCHEMIA trial, we aim to set the record straight on the benefits of coronary artery bypass grafting (CABG) and the misinterpretation of this landmark trial. We sought to clarify and reorient this misinterpretation.

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Objectives: We explored the current evidence on coronary disease treatment comparing the survival of 2 therapeutic strategies: coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) with drug-eluting stent (DES).

Methods: PubMed, Embase, and Google Scholar were searched for randomized clinical trials comparing CABG versus PCI with DES. The end point was overall mortality.

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Objectives: Most evidence for anticoagulation (AC) in aortic bioprosthesis is centred on embolic events, bleeding and reintervention risk. The effect of AC on haemodynamics has not been previously assessed. Our hypothesis was that patients with early AC after aortic valve replacement (AVR) with porcine bioprosthesis have better haemodynamics at 1 year of follow-up.

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Introduction: There is a lack of information about cardiac surgery training and professional practice in Latin American (LATAM) countries. This study is the first comparative analysis of cardiac surgical training and professional practice across LATAM and provides the fundamentals for future academic projects of the Latin American Association of Cardiac and Endovascular Surgery (LACES).

Methods: International survey-based comparative analysis of the training and professional practice of cardiac surgeons across LATAM.

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Introduction: Since the coronavirus disease 2019 (COVID-19) pandemic, cardiac surgeries in patients with previous infection by COVID-19 were suspended or postponed, which led to surgeries performed in patients with an advanced stage of their disease and an increase in the waiting list. There is a heterogeneous attitude in Latin America on the optimal timing to cardiac surgery in patients with previous COVID-19 infection due to scarce data on its outcome. Two Latin American associations joined to establish common suggestions on the optimal timing of surgery in patients with previous COVID-19 infection.

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