Social bonding through shared experiences: the role of emotional intensity.

Sharing emotions with other individuals is a widespread phenomenon. Previous research proposed that experiencing intense and similar emotions with other individuals reinforces social bonds. However, several aspects of this phenomenon remain unclear, notably whether social bonding requires the convergence and synchronization of emotions in the group, and whether these effects generalize across positively valenced and negatively valenced emotional contexts.

Use of Costal Perichondrium as an Interpositional Graft for Septal Perforation Closure.

Importance: Closure of septal perforations remains a technically difficult procedure to perform.

Objective: To assess the use of costal perichondrium as an interpositional graft to enhance closure of septal perforations using bilateral mucosal flaps and the effectiveness of the procedure.

Design, Setting, And Participants: This case series included all 51 consecutive patients presenting with septal perforations from January 1, 2006, to August 31, 2014, at a single institution.

Surgical Adhesives in Facial Plastic Surgery.

In facial plastic surgery, attaining hemostasis may require adjuncts to traditional surgical techniques. Fibrin tissue adhesives have broad applications in surgery and are particularly useful when addressing the soft tissue encountered in facial plastic surgery. Beyond hemostasis, tissue adhesion and enhanced wound healing are reported benefits associated with a decrease in operating time, necessity for drains and pressure dressings, and incidence of wound healing complications.

Pediatric nasal valve surgery: short-term outcomes and complications.

Objectives: To examine the short-term outcomes and complications of open nasal valve surgery in children under 16 years of age.

Study Design: case series and chart review study setting: an urban, tertiary, pediatric otolaryngology practice.

Methods: Children under 16 years of age who had undergone nasal valve surgery with cartilage grafting for functional indications were identified.

Cervical necrotizing fasciitis in children under two years of age.

We present two cases of life-threatening, necrotizing infections of the head and neck region, a rare infectious process in young children, that progressed to bacteremia and sepsis in two toddlers. To date there have been no reports of cervical necrotizing fasciitis in toddlers under two years of age. Immunocompromised children may be at higher risk for developing fulminent infections.

Identification of a molecular recognition role for the activation loop phosphotyrosine of the SRC tyrosine kinase.

A human cDNA phage display library screen, using a phosphopeptide designed to mimic the activation loop phosphotyrosine of the Src tyrosine kinase, has identified the N-terminal SH2 domain of the p85 regulatory subunit of phosphatidyl inositol-3 kinase (PI3K) as an interacting recognition domain. Activation loop phosphorylation is known to play a conformational role in kinase activation, but is largely not thought to play a role in protein/protein recognition. Affinity chromatography and biochemical evaluation in mouse fibroblast cells has confirmed the dependence of this interaction on both the Src activation loop phosphotyrosine and the N-terminal SH2 domain of PI3K.

Two-dimensional diversity: screening human cDNA phage display libraries with a random diversity probe for the display cloning of phosphotyrosine binding domains.

A random phosphopeptide probe (bio-pYZZZ) has been used for the isolation and identification of multiple SH2 domains from human cDNA-displaying phage libraries. In addition, on-phage analysis and quantification of binding affinities for these phage-displayed proteins has shown them to be functional domains, retaining the same characteristics as in their native state.