Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from .

The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investigating the structure and function of the various nAChR subtypes. By studying how conotoxins interact with nAChRs, we can improve our understanding of these receptors, leading to new insights into neurological diseases associated with nAChRs.

Topological order in a correlated three-dimensional topological insulator.

Motivated by experimental progress in the growth of heavy transition metal oxides, we theoretically study a class of lattice models of interacting fermions with strong spin-orbit coupling. Focusing on interactions of intermediate strength, we derive a low-energy effective field theory for a fully gapped, topologically ordered, fractionalized state with an eightfold ground-state degeneracy. This state is a fermionic symmetry-enriched topological phase with particle-number conservation and time-reversal symmetry.