Dichotomous Effects of Glypican-4 on Cancer Progression and Its Crosstalk with Oncogenes.

Glypicans are linked to various aspects of neoplastic behavior, and their therapeutic value has been proposed in different cancers. Here, we have systematically assessed the impact of GPC4 on cancer progression through functional genomics and transcriptomic analyses across a broad range of cancers. Survival analysis using TCGA cancer patient data reveals divergent effects of expression across various cancer types, revealing elevated expression levels to be associated with both poor and favorable prognoses in a cancer-dependent manner.

Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior.

Glypicans (GPC1-6) are associated with tumorigenic processes and their involvement in neoplastic behavior has been discussed in different cancer types. Here, a cancer-wide GPC expression study, using clinical cancer patient data in The Cancer Genome Atlas, reveals net upregulation of and in primary solid tumors, whereas , and display lowered expression pattern compared to normal tissues. Focusing on , survival analyses of the clinical cancer patient data reveal statistically significant correlation between high expression of and poor prognosis in 10 particular cancer types i.