High-Grade Neuroendocrine Carcinoma Within a Tracheal Polyp: A Case Report.

Introduction: Primary carcinomas of the trachea are rare, with a reported annual incidence of one in a million. We present a case of a previously undescribed polypoid high-grade neuroendocrine carcinoma of the trachea. Resection of the carcinoma revealed only superficial invasion of the mucosa and without evidence of local or distant metastatic disease.

Metastatic adenoid cystic carcinoma with high-grade transformation ("dedifferentiation") in pleural effusion and neck lymph node: A diagnostic challenge on cytology?

High-grade transformation (HGT) or "dedifferentiation" is an uncommon phenomenon among salivary gland carcinomas including adenoid cystic carcinoma (ACC), which is important to recognize because it is associated with increased tumor aggressiveness, with a high propensity for lymph node and distant metastases. ACC with HGT is histologically characterized by a distinct population of poorly differentiated cells with loss of the typical biphasic ductal and myoepithelial differentiation seen in conventional ACC, associated with pleomorphism, necrosis and increased mitotic activity. We report the cytologic features of a case of metastatic ACC-HGT in cervical lymph node and effusion, which, to the best of our knowledge, have not been described previously.