Development and Characterization of Celecoxib Solid Self-nanoemulsifying Drug Delivery Systems (S-SNEDDS) Prepared Using Novel Cellulose-Based Microparticles as Adsorptive Carriers.

Self-nanoemulsifying drug delivery systems (SNEDDS) represent an interesting platform for improving the oral bioavailability of poorly soluble lipophilic drugs. While Liquid-SNEDDS (L-SNEDDS) effectively solubilize the drug in vivo, they have several drawbacks, including poor storage stability. Solid-SNEDDS (S-SNEDDS) combine the advantages of L-SNEDDS with those of solid dosage forms, particularly stability.

Starch-Based Aerogels Obtained via Solvent-Induced Gelation.

In this work, the ability of several solvents to induce gel formation from amylomaize starch solubilized in dimethyl sulfoxide (DMSO) was investigated. The formed gels were subjected to solvent exchange using ethanol and dried with supercritical carbon dioxide (sc-CO) to obtain the aerogels. The influence of starch concentration (3-15 wt%) and solvent content (20-80 wt%) on gel formation was also studied.

Cellulose Aerogel Microparticles via Emulsion-Coagulation Technique.

Cellulose aerogel microparticles were made via emulsification/nonsolvent induced phase separation/drying with supercritical CO. Cellulose was dissolved in NaOH-based solvent with and without additives in order to control solution gelation. Two emulsions, cellulose solution/oil and cellulose nonsolvent/oil, were mixed to start nonsolvent induced phase separation (or coagulation) of cellulose inside each cellulose droplet leading to the formation of so-called microgels.

Porous Starch Materials via Supercritical- and Freeze-Drying.

The production of porous materials based on starch has been explored with supercritical drying-yielding aerogel-and freeze-drying. The two drying procedures were applied on the same gelling solution of amylomaize starch pasted at 140 °C and for two concentrations (5 and 10 wt.%).

Review on the Production of Polysaccharide Aerogel Particles.

A detailed study of the production of polysaccharide aerogel (bio-aerogel) particles from lab to pilot scale is surveyed in this article. An introduction to various droplets techniques available in the market is given and compared with the lab scale production of droplets using pipettes and syringes. An overview of the mechanisms of gelation of polysaccharide solutions together with non-solvent induced phase separation option is then discussed in the view of making wet particles.