A Different View for an Old Disease: NEDDylation and Other Ubiquitin-Like Post-Translational Modifications in Chronic Lymphocytic Leukemia.

Despite the enormous amount of molecular data obtained over the years, the molecular etiology of chronic lymphocytic leukemia (CLL) is still largely unknown. All that information has enabled the development of new therapeutic approaches that have improved life expectancy of the patients but are still not curative. We must increase our knowledge of the molecular alterations responsible for the characteristics common to all CLL patients.

Stability studies of binary mixtures of haloperidol and/or midazolam with other drugs for parenteral administration.

Background: Haloperidol and or midazolam are frequently combined with other drugs in the same solution and infused parenterally over several days to treat symptoms. The solutions may be delivered to the home well in advance of the time of administration. Consequently, physiochemical stability of these combinations needs to be studied.