Efficacy of maropitant for treatment and prevention of emesis caused by intravenous infusion of cisplatin in dogs.

Objective: To evaluate the efficacy of maropitant, a novel neurokinin-1 receptor antagonist, to treat and prevent emesis caused by IV infusion of a chemotherapeutic dose of cisplatin (70 mg/m(2)) in dogs.

Animals: 64 healthy 6-month-old Beagles (32 males and 32 females).

Procedures: To evaluate the effect of maropitant on ongoing emesis, 24 dogs were randomized to 2 treatment groups (12 dogs each).