Publications by authors named "Victor A Herrera"
Article Synopsis
- Cataract is a major cause of blindness in older adults and is influenced by genetic factors, with a heritability estimate of 58%.
- The study utilized a transcriptome-wide association study (TWAS) to discover and prioritize novel genes associated with cataract by analyzing gene expression from 54 different tissues.
- The researchers found 99 genes linked to cataract, with 20 being newly identified, and noted that gastrointestinal tissues showed a significant connection to these gene associations.
Genome-wide association studies (GWASs) have identified more than 130 genetic susceptibility loci for migraine; however, how most of these loci impact migraine development is unknown. To identify novel genes associated with migraine and interpret the transcriptional products of those genes, we conducted a transcriptome-wide association study (TWAS). We performed tissue-specific and multi-tissue TWAS analyses to assess associations between imputed gene expression from 53 tissues and migraine susceptibility using FUSION software.
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