Publications by authors named "Victor A H Sato"
Overlap of membranous nephropathy and IgA nephropathy in a patient with Kimura's disease: a case report and literature review.
Front Immunol
July 2024
Article Synopsis
- A 27-year-old man with KD presented symptoms like leg edema, cervical mass, and high eosinophil levels, leading to diagnoses of overlapping membranous nephropathy and IgA nephropathy.
- Treatment involved prednisone and methotrexate, resulting in a reduction of the cervical mass and improvement in kidney function, indicating a need to monitor kidney health in KD patients.
Primary Effusion Lymphoma is an extremely rare and aggressive subtype of B-cell lymphoma, accounting for only <1% of all cases of this neoplasm. It has a unique clinical presentation because it has a predilection for appearing in body cavities, such as the pleural space, pericardium and peritoneum. It mainly affects immunocompromised individuals and may also affect individuals in the Mediterranean region and in areas endemic for human herpesvirus 8 (HHV-8).
View Article and Find Full Text PDFBackground: Insulin resistance and/or hyperinsulinemia are closely linked to adiposity, metabolic syndrome (MetS) and prolonged inflammatory processes.
Methods: We retrospectively analyzed 1,018 adult individuals with a mean age of 46 years (74% male) and classified them as: Metabolically normal: without any of the five criteria of the International Diabetes Federation (IDF) used for the diagnosis of MetS, plus normal fasting insulin (Men < 8 mU/L, Women < 10 mU/L); Level 1 MetS: with one or two IDF criteria, plus hyperinsulinemia (Men: ≥ 8 mU/L), and Women: ≥ 10 mU/L); Level 2 MetS: with three or more IDF criteria, plus hyperinsulinemia.
Results: The mean values for fasting insulinemia in metabolically normal individuals was 4.
Mycophenolate rapidly substituted azathioprine (AZA) in transplant immunosuppression regimens since the 1990s, when early clinical trials indicated better outcomes, although opposite results were also observed. However, none of these trials used the well-established optimization methods for AZA dosing, namely, thiopurine methyltransferase pharmacogenetics combined with monitoring of the thiopurine metabolites 6-thioguanine nucleotides (6-TGN) and 6-methylmercaptopurine (6-MMP). Resistance to optimize AZA therapy remains today in transplant therapy, despite the fact that thiopurine metabolite testing is being used by other medical disciplines with evident improvement in clinical results.
View Article and Find Full Text PDFCardiovascular disease is the main cause of death in patients with chronic kidney disease (CKD). Several heart conditions have been associated with CKD, including myocardial and pericardial diseases. This paper describes a case of Dialysis-related constrictive pericarditis in a patient diagnosed with sudden hypotension during a hemodialysis session.
View Article and Find Full Text PDFArticle Synopsis
- The study focused on acute kidney injury (AKI) in COVID-19 patients in a Brazilian ICU, analyzing data from 95 patients with a median age of 64.9 years and a predominance of males (64.2%).
- It found that 56.8% of the patients had AKI, with a significant number (59.2%) requiring hemodialysis and a mortality rate of 17.9%.
- Key risk factors for developing AKI included hypertension, the need for mechanical ventilation, and age over 65, while AKI itself was identified as an independent risk factor for increased mortality.
An elderly diabetic patient with McArdle disease and recurrent rhabdomyolysis: a potential association with late hypoinsulinemia?
BMC Geriatr
November 2020
Background: McArdle disease is a myopathy caused by mutations in PYGM gene that is characterized by reduced or absent activity of myophosphorylase. Reports of patients with concomitant McArdle disease and diabetes are scarce. We report a case of a patient with a late diagnosis of McArdle disease and we postulate that symptoms may be related to hypoinsulinemia.
View Article and Find Full Text PDFBackground: Cyst infection is a prevalent complication in autosomal dominant polycystic kidney disease (ADPKD) patients, however therapeutic and diagnostic approaches towards this condition remain unclear. The confirmation of a likely episode of cyst infection by isolating the pathogenic microorganism in a clinical scenario is possible only in the minority of cases. The available antimicrobial treatment guidelines, therefore, might not be appropriate to some patients.
View Article and Find Full Text PDFBackground: Among kidney transplant recipients (KTRs), tuberculosis is one of the most common opportunistic infections and is associated with high morbidity and mortality. The aim of this study was to describe the incidence, clinical features, and prognosis of tuberculosis in KTRs.
Methods: Retrospective single-center observational study involving all cases of tuberculosis in KTRs between 2000 and 2010.