Synopsis of recent research by authors named "Vickie Tsui"
- Vickie Tsui's research primarily focuses on the design and development of selective small molecule inhibitors that target bromodomains and kinases, contributing to advancements in drug discovery for various oncological applications.
- Significant findings from her work include the development of highly potent and selective inhibitors for bromodomains, along with insights on optimizing small-molecule interactions at protein-ligand interfaces, demonstrating the impact of water molecules in increasing inhibitor potency.
- Tsui's studies also highlight the therapeutic potential of inhibiting enzymes such as USP7 and TYK2, showcasing successful candidates like GDC-0339 for multiple myeloma and imidazopyridine-based inhibitors for psoriasis, thus paving the way for new treatments in oncology and autoimmune diseases.