Publications by authors named "Vickie M Wang"
Article Synopsis
- - Both neurons and glia use neuromodulatory substances to communicate, but how they compute information in these networks is not fully understood.
- - In larval zebrafish, norepinephrine causes quick excitation followed by delayed behavior inhibition, which is partially mediated by astroglial release of ATP that converts to adenosine to suppress behavior.
- - This study, along with another involving mice, highlights the important role of astroglial purinergic signaling in regulating behavior and brain activity transitions driven by norepinephrine, showcasing a conserved mechanism across species.
Although genomic analyses predict many noncanonical open reading frames (ORFs) in the human genome, it is unclear whether they encode biologically active proteins. Here we experimentally interrogated 553 candidates selected from noncanonical ORF datasets. Of these, 57 induced viability defects when knocked out in human cancer cell lines.
View Article and Find Full Text PDFAnti-cancer uses of non-oncology drugs have occasionally been found, but such discoveries have been serendipitous. We sought to create a public resource containing the growth inhibitory activity of 4,518 drugs tested across 578 human cancer cell lines. We used PRISM, a molecular barcoding method, to screen drugs against cell lines in pools.
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