Short-term and long-term outcomes for overweight dogs with cranial cruciate ligament rupture treated surgically or nonsurgically.

Objective: To determine short- and long-term rates of successful outcomes of surgical and nonsurgical treatments for overweight dogs with cranial cruciate ligament rupture (CCLR).

Design: Prospective, randomized, clinical trial. Animals-40 client-owned overweight dogs with unilateral CCLR.

Inflammation, apoptosis, and necrosis induced by neoadjuvant fas ligand gene therapy improves survival of dogs with spontaneous bone cancer.

Fas ligand (FasL) gene therapy for cancer has shown promise in rodents; however, its efficacy in higher mammals remains unknown. Here, we used intratumoral FasL gene therapy delivered in an adenovirus vector (Ad-FasL) as neoadjuvant to standard of care in 56 dogs with osteosarcoma. Tumors from treated dogs had greater inflammation, necrosis, apoptosis, and fibrosis at day 10 (amputation) compared to pretreatment biopsies or to tumors from dogs that did not receive Ad-FasL.

Gene expression in intestinal mucosal biopsy specimens obtained from dogs with chronic enteropathy.

Objective: To characterize mucosal gene expression in dogs with chronic enteropathy (CE).

Animals: 18 dogs with CE and 6 healthy control dogs.

Procedures: Small intestinal mucosal biopsy specimens were endoscopically obtained from dogs.

Two cases of paraprostatic cysts in castrated male dogs.

Two castrated male dogs presented for evaluation of tenesmus. Presurgical evaluations included complete physical examinations, serum biochemistry, abdominal ultrasonography, and MRI (case 2 only). Paraprostatic cysts were diagnosed in both cases based on the results of abdominal ultrasonography, MRI, and histopathology of tissue samples obtained during exploratory laparotomy.

Serum cortisol concentration and force plate analysis in the assessment of pain associated with sodium urate-induced acute synovitis in dogs.

Objective: To determine the relationship between serum cortisol concentration and pain severity as measured by force platform gait analysis in dogs with experimentally induced synovitis of the stifle joint.

Animals: 10 healthy hound-type dogs.

Procedures: Dogs underwent 2 study phases.

Thyroid cancer in dogs: an update based on 638 cases (1995-2005).

The goal of this study was to update the descriptive statistics of thyroid cancer by using data from multiple institutions collected through the Veterinary Medical Database (VMDB). Information was collected and reported from cases of canine thyroid cancer submitted to the VMDB between January 1, 1995 and December 31, 2005. Odds ratio (OR) analysis was performed on breeds that had > or =3% of the total number of dogs with thyroid cancer; ORs for each age category were also determined.

Nasal rhinosporidiosis in two dogs native to the upper Mississippi river valley region.

Two dogs, 4 and 7 years of age, were presented for evaluation and treatment of excessive sneezing. Physical examinations in both cases were within acceptable limits except for the presence of a single mass in the left nasal passage in the first case and left-sided nasal discharge in the second case. Rhinoscopy was used to visualize the nasal masses, and in both cases a single mass was surgically removed.

Identification of chromosomal regions associated with cranial cruciate ligament rupture in a population of Newfoundlands.

Objective: To identify chromosomal regions associated with cranial cruciate ligament rupture (CCLR) in a population of Newfoundlands.

Animals: 90 client-owned Newfoundlands.

Procedures: A pedigree was constructed for dogs that did or did not have CCLR (determined on the basis of physical examination and radiographic findings).

Inheritance of rupture of the cranial cruciate ligament in Newfoundlands.

Objective: To determine prevalence, level of inbreeding, heritability, and mode of inheritance for rupture of the cranial cruciate ligament (RCCL) in Newfoundlands.

Design: Retrospective and recruitment study.

Animals: 574 client-owned Newfoundlands.

Estimate of the annual economic impact of treatment of cranial cruciate ligament injury in dogs in the United States.

Objective: To estimate the economic impact to veterinary clients for the medical and surgical treatment of rupture of the cranial cruciate ligament (RCCL) in dogs for the year 2003.

Design: Economic impact survey.

Sample Population: 501 diplomates of the American College of Veterinary Surgeons (ACVS) indicating that their area of surgical emphasis was small animal orthopedic surgery or small animal general and orthopedic surgery and 4,000 veterinarians indicating to the AVMA that their professional area was small animal practice exclusive or mixed animal practice (at least 80% small animal).

The relationship between limb function and radiographic osteoarthrosis in dogs with stifle osteoarthrosis.

Objective: To evaluate the relationship between limb function and radiographic evidence of stifle osteoarthrosis (OA) in dogs.

Study Design: The relationship between force platform data and radiographic OA score was evaluated on 2 separate days using regression analysis. Interday variation was also assessed.

Comparison of tibial plateau angle between clinically normal Greyhounds and Labrador Retrievers with and without rupture of the cranial cruciate ligament.

Objective: To compare tibial plateau angle (TPA) between Greyhounds without damage to the cranial cruciate ligaments and Labrador Retrievers with and without damage to the cranial cruciate ligaments.

Design: Clinical study.

Animals: 87 client-owned dogs and 15 research colony Greyhounds.