Publications by authors named "Vicki Wiles"
Article Synopsis
- Germline gene pathogenic variants significantly increase cancer risk, prompting the UK to recommend annual MRI screenings for female carriers, as supported by the SIGNIFY study which suggests whole-body MRI is beneficial for all adult carriers.* -
- The study found that while whole-body MRI screening was acceptable and resulted in high satisfaction and low psychological distress, carriers experienced greater cancer-related worries and intrusive thoughts compared to control groups.* -
- The findings suggest that WB-MRI screenings do not lead to negative psychosocial effects, and it highlights the need for support and coping strategies for carriers, especially those who underestimate their cancer risks.*
In the United Kingdom, current screening guidelines for TP53 germline mutation carriers solely recommends annual breast MRI, despite the wide spectrum of malignancies typically seen in this group. This study sought to investigate the role of one-off non-contrast whole-body MRI (WB MRI) in the screening of asymptomatic TP53 mutation carriers. 44 TP53 mutation carriers and 44 population controls were recruited.
View Article and Find Full Text PDFDespite it being generally acknowledged that counseling supervision is a vital part of the work for experienced genetic counselors and not just students, not all practising genetic counselors in the United Kingdom and Eire have access to this yet. This case study documents the supervision experience of our team of genetic counselors from Cambridge in the U.K.
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