A single-institution retrospective analysis of pathologically determined malignant transformation in mutant glioma patients.

Background: Lower-grade mutant glioma patients frequently undergo malignant transformation (MT), with apparent worse prognosis. Many studies examine MT in mixed status cohorts and define MT using imaging, not histopathology. Our study examines the timing, predictors, and prognostic implications of pathologically determined MT in a large, exclusively mutant cohort.

Retrospective examination of pseudoprogression in mutant gliomas.

Background: Tumor surveillance of isocitrate dehydrogenase () mutant gliomas is accomplished via serial contrast MRI. When new contrast enhancement (CEnew) is detected during postsurgical surveillance, clinicians must assess whether CEnew indicates pseudoprogression (PsP) or tumor progression (TP). PsP has been better studied in wild-type glioblastoma but has not been well characterized in mutant gliomas.

In vivo safety evaluation of polyarginine coated magnetic nanovectors.

Safety and efficacy are of critical importance to any nanomaterial-based diagnostic and therapy. The innocuity and functionality of a nanomaterial in vivo is largely dependent on the physicochemical properties of the material, particularly its surface coating. Here, we evaluated the influence of polycationic coating on the efficacy, clearance organ uptake, and safety of magnetic nanovectors designed for siRNA delivery.

Effect of alcoholic beverages on postprandial glycemia and insulinemia in lean, young, healthy adults.

Background: Ethanol's ability to inhibit gluconeogenesis might reduce postprandial glycemia in realistic meal settings.

Objective: The objective was to explore the effect of 3 types of alcoholic beverages consumed alone, with a meal, or 1 h before a meal on postprandial glycemia in healthy subjects.

Design: In study 1, isoenergetic (1000 kJ) servings of beer, white wine, and gin were compared with a 1000-kJ portion of white bread.

The glycemic index of foods influences postprandial insulin-like growth factor-binding protein responses in lean young subjects.

Background: Growth in normal and malignant tissues has been linked to hyperinsulinemia and insulin-like growth factors (IGFs). We hypothesized that IGF and IGF-binding protein (IGFBP) responses may be acutely affected by differences in the glycemic index (GI) of foods.

Objective: We compared the postprandial responses of IGFs and IGFBP to 2 foods of similar macronutrient composition but with greatly different GIs-pearled barley (GI: 25) and instant mashed potato (GI: 85).