Speak up & reach out: In defense of biomedical research.

Scientists face challenges in communicating about their careers in biomedical research to the public, despite the importance of doing so. Here, we discuss tools and resources for outreach, such as posters, videos, and presentations that can be leveraged by scientists to help educate communities about the pivotal role of animals in medical progress.

Comparison between laparoscopic and robotic surgery for sentinel lymph node mapping in endometrial cancer using indocyanine green and near infra-red fluorescence imaging.

Indocyanine green (ICG) and near infra-red fluorescence imaging in minimally invasive surgery is an option to map sentinel lymph nodes (SLN). The aim of this study was to compare the outcomes of SLN mapping between laparoscopic and robotic surgery. One-hundred-and-forty women with histologically confirmed endometrial cancer, were treated with a minimally invasive hysterectomy, bilateral salpingo-oophorectomy and SLN mapping.

Implementing patient information for gynae-oncology patients at a tertiary referral health service.

Aim: To ensure that gynae-oncology surgical patients receive relevant written information, in their preferred format, and at a time that suits them, according to the best available evidence.

Methods: This project utilized an audit and feedback design and was conducted over a 9-month period from August 2015 to May 2016. Twenty-nine patients were audited prior to two strategies being implemented.

Collateral circulation in ferrets (Mustela putorius) during temporary occlusion of the caudal vena cava.

OBJECTIVE To determine whether extent of collateral circulation would change during temporary occlusion of the caudal vena cava (CVC) in ferrets (Mustela putorius), a pressure change would occur caudal to the occlusion, and differences would exist between the sexes with respect to those changes. ANIMALS 8 adult ferrets (4 castrated males and 4 spayed females). PROCEDURES Ferrets were anesthetized.

Comparison of axillary and rectal temperatures for healthy Beagles in a temperature- and humidity-controlled environment.

Objective: To compare axillary and rectal temperature measurements obtained with a digital thermometer for Beagles in a temperature- and humidity-controlled environment.

Animals: 26 healthy Beagles (17 sexually intact males and 9 sexually intact females).

Procedures: Dogs were maintained in a temperature- and humidity-controlled environment for 56 days before rectal and axillary temperatures were measured.

Comparison of tissue oxygen saturation in ovariohysterectomized dogs recovering on room air versus nasal oxygen insufflation.

Objective: To compare tissue oxygen saturation in ovariohysterectomized dogs recovering postoperatively on room air versus nasal oxygen insufflation.

Design: Prospective clinical study.

Setting: University teaching hospital.

Respiratory complications in critical illness of small animals.

The percentage of emergency patients with respiratory problems treated at veterinary emergency and critical care facilities is poorly defined. Regardless of whether an animal has a primary lung disease or develops a secondary lung disease during hospitalization, acute respiratory distress syndrome (ARDS) is a common sequela to the failing lung. ARDS is a frequent sequela to sepsis, systemic inflammatory response (SIRS), and disseminated intravascular coagulation and is frequently the pulmonary manifestation of multiple organ dysfunction syndrome (MODS).

Evaluation of open versus closed urine collection systems and development of nosocomial bacteriuria in dogs.

Objective: To determine whether use of a closed urine collection system would decrease the incidence of nosocomial bacteriuria in hospitalized dogs, compared with use of an open urine collection system (used, sterile IV bags).

Design: Randomized controlled trial.

Animals: 51 hospitalized dogs requiring indwelling urinary catheterization for >or= 24 hours.

Assessment of oxygen transport and utilization in dogs with naturally occurring sepsis.

Objective: To compare cardiac index (CI), oxygen delivery index (D(O(2))I), oxygen extraction ratio (O(2)ER), oxygen consumption index (V(O(2))I), and systemic vascular resistance index (SVRI) in dogs with naturally occurring sepsis with published values for healthy dogs; compare those variables in dogs with sepsis that did or did not survive; and compare CI and D(O(2))I in dogs with sepsis with values in dogs with nonseptic systemic inflammatory response syndrome (nSIRS).

Design: Cohort study.

Animals: 10 dogs with naturally occurring sepsis and 11 dogs with nSIRS.

Measurement of urinary F2-isoprostanes as markers of in vivo lipid peroxidation: a comparison of enzyme immunoassays with gas chromatography-mass spectrometry in domestic animal species.

F(2)-isoprostanes are useful markers for assessing oxidant injury; however, the validity of measuring urinary 15-F(2t)-isoprostane concentration by enzyme-linked immunosorbent assay (ELISA) has not been evaluated in veterinary species. The current study assesses the agreement between 2 commercially available urinary isoprostane kits and gas chromatography and negative ion chemical ionization-mass spectrometry (GC/NICI-MS). The results indicate that only feline urinary isoprostane measurement by glucuronidase (GL)-ELISA has acceptable agreement with GC/NICI-MS.

Comparison of continuous arterial pressure waveform analysis with the lithium dilution technique to monitor cardiac output in conscious dogs with systemic inflammatory response syndrome.

Objective: To assess the agreement between cardiac output (CO) measured by use of arterial pressure waveform analysis (PulseCO) and lithium dilution (LiDCO) in conscious dogs with systemic inflammatory response syndrome (SIRS).

Animals: 14 dogs with naturally occurring SIRS.

Procedures: Pulse power analysis was performed on critically ill patients with a PulseCO monitor.

Use of a point-of-care urine drug test in a dog to assist in diagnosing barbiturate toxicosis secondary to ingestion of a euthanized carcass.

Objective: To describe a case of barbiturate toxicosis in a dog secondary to ingestion of a previously buried euthanized goat carcass and to discuss the utility of urine drug testing in diagnosing barbiturate toxicosis.

Case Summary: A 6-year-old neutered male Border Collie was presented to a university veterinary teaching hospital for evaluation of ataxia and acute collapse. Past pertinent history included Addison's disease that had been managed for 1 year.

Aerobic bacterial culture of used intravenous fluid bags intended for use as urine collection reservoirs.

Numerous studies have shown a relationship between indwelling urinary catheters and bacterial urinary tract infection. Some veterinary hospitals utilize stored, used intravenous (IV) fluid bags as part of the urine collection system. The authors cultured 95 such bags to see if they were potential sources of bacterial contamination.

The effects of surgery and anesthesia on blood magnesium and calcium concentrations in canine and feline patients.

Objective: To demonstrate the effect of anesthesia and surgery on serum ionized magnesium and ionized calcium concentrations in clinical canine and feline patients.

Animals: 37 client-owned dogs, ASA PS I-III and 10 client-owned cats, ASA PS I, all receiving anesthesia for elective or emergent surgery at a Veterinary Teaching Hospital.

Materials And Methods: Plasma ionized and serum total magnesium, and plasma ionized calcium were measured prior to and after a group-standardized anesthetic protocol.

Anesthetic protocols for common emergencies.

Anesthesia, sedation, and pain management should be taken seriously in the emergency patient. Proper knowledge of the drugs available and their pharmacokinetics and pharmacodynamics are necessary to administer anesthesia safely to critical patients. A proactive approach regarding monitoring, titration of anesthetic drugs, and anticipation of life-threatening complications helps in achieving successful anesthetic outcomes.

Postoperative hypoxemia and hypercarbia in healthy dogs undergoing routine ovariohysterectomy or castration and receiving butorphanol or hydromorphone for analgesia.

Objective: To determine frequency and severity of postanesthetic hypoxemia and hypercarbia in healthy dogs undergoing elective ovariohysterectomy or castration and given butorphanol or hydromorphone for analgesia.

Design: Prospective trial.

Animals: 0 healthy dogs weighing > 10 kg (22 lb).