Publications by authors named "Vicentiu Vlaia"
Article Synopsis
- * In vitro tests on healthy skin cell lines showed that the hydrogels had a good biosafety profile, with no significant toxicity or harmful effects observed after exposure.
- * Additional in vivo studies on mice and chicken embryos confirmed the hydrogels' biocompatibility, but further research is necessary to assess their long-term therapeutic effects and clinical application potential.
In Tunisia, self-medication is a common practice, and there is a continual rise in the prevalence of cardiovascular disease. Given the lack of data on the self-medication practices (SMPs) among cardiovascular patients in this area, the present study aimed to identify the prevalence and determinants of SMPs among cardiovascular patients in the city of Béja. A community-pharmacy-based survey was conducted among selected cardiovascular patients in Béja, Tunisia, from May 2021 to June 2021.
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- Biocompatible gel microemulsions using essential oils like cinnamon, oregano, and clove have been developed to improve the skin absorption and effectiveness of the antifungal drug fluconazole.
- The study focused on enhancing the adhesion of these microemulsions by incorporating chitosan, a biopolymer with antifungal properties, and analyzed how different formulation components affected their overall performance.
- Results indicated that specific formulations significantly improved drug release and antifungal activity, showcasing these microemulsions as effective delivery systems for topical fluconazole treatments.
Background: Curcuma longa Linnaeus and Zingiber officinale Roscoe are two main representatives of Zingiberaceae family studied for a wide range of therapeutic properties, including: antioxidant, anti-inflammatory, anti-angiogenic, antibacterial, analgesic, immunomodulatory, proapoptotic, anti-human immunodeficiency virus properties and anticancer effects. This study was aimed to analyse the ethanolic extracts of Curcuma rhizome (Curcuma longa Linnaeus) and Zingiber rhizome (Zingiber officinale Roscoe) in terms of polyphenols, antioxidant activity and anti-melanoma potential employing the B164A5 murine melanoma cell line.
Results: In order to evaluate the total content of polyphenols we used Folin-Ciocâlteu method.
The aim of the present investigation was to develop and evaluate microemulsion-loaded hydrogels (MEHs) for the topical delivery of fluconazole (FZ). The solubility of FZ in oils, surfactants and cosurfactants was evaluated to identify the components of the microemulsion. The pseudo-ternary phase diagrams were constructed using the novel phase diagram by micro-plate dilution method.
View Article and Find Full Text PDFA comparative study of 36 molecular descriptors derived from the topological distance matrix and van der Waals space is carried out within this paper. They are partitioned into 16 generalized topological distance matrix indices, 11 topological distance indices known in the literature (seven obtained from eigenvalues/eigenvectors of distance matrix), and 9 van der Waals molecular descriptors. The generalized topological distance indices, (k)delta(lambda) (lambda = 1 - 3, k = 1 - 4), are introduced in this work on the basis of reciprocical distance matrix.
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