Publications by authors named "Vicente F C Andrade"
Article Synopsis
- This study aimed to assess how the size of growth hormone-secreting pituitary adenomas at diagnosis affects various characteristics of patients with acromegaly, including clinical, laboratory, and treatment outcomes.
- Researchers analyzed data from 117 patients, categorizing them based on adenoma size and found that larger tumors (≥20 mm) were linked to higher rates of complications and poorer treatment responses compared to smaller tumors (<20 mm).
- The study concluded that smaller adenomas (under 20 mm) are associated with lower morbidity and better treatment efficacy, while larger adenomas exhibit similar clinical issues regardless of size.
No evidence of mineralization abnormalities in iliac bone of premenopausal women with type 2 diabetes mellitus.
J Musculoskelet Neuronal Interact
September 2022
Objectives: Patients with type-2 diabetes mellitus (T2DM) have increased risk for bone fractures which points towards impaired bone quality.
Methods: We measured bone mineralization density distribution (BMDD) and osteocyte lacunae section (OLS) characteristics based on quantitative backscattered electron images of transiliac biopsy samples from n=26 premenopausal women with T2DM. Outcomes were compared to those from reference cohorts as well as between T2DM subgroups defined by clinical characteristics.
Context: No study has yet evaluated the relationships among bone marrow adiposity (BMA), bone histomorphometry (BH), and glycemic control in premenopausal women with type 2 diabetes (T2DM).
Objective: We aimed to assess the effect of glycemic control on BMA, correlate the parameters of BH with BMA, and correlate BMA with the use of hypoglycemic agents and with bone mineral density (BMD).
Methods: This was a cross-sectional study that evaluated 26 premenopausal women with T2DM who were divided into groups with HbA1c < 7% (good control [GC], n = 10) and HbA1c > 7% (poor control [PC], n = 16).
Type 2 diabetes mellitus (T2DM) patients are at an increased risk of fracture despite normal to high bone mineral density (BMD) values. In this cross-sectional study we establish bone compositional properties in tetracycline labeled iliac crest biopsies from premenopausal women diagnosed with T2DM (N = 26). Within group comparisons were made as a function of tissue age (TA), presence of chronic complications (CC), glycosylated haemoglobin (HbA1c) levels, and morphometric fracture (MFx).
View Article and Find Full Text PDFContext: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of fractures. No study has evaluated the correlation of bone histomorphometry (BH) parameters with glycemic control and presence of chronic complications (CCs) in premenopausal women with T2DM.
Objectives: To evaluate BH and correlate them with the degree of glycemic control and presence of CCs.