Targeted Isolation of Anti-inflammatory Lignans from by Molecular Networking Approach.

Herein, the isolation of secondary metabolites from the aerial parts of guided by HPLC-MS and molecular networking analyses is reported. Twenty-two known compounds were dereplicated. Three new lignans (aequilabrines A-C (-)) and three known compounds (lariciresinol-4'-β-glucose (), roseoside (), and allantoin ()) were obtained.

Toxicological and Pharmacological Activities of (Benth.) Harley and J.F.B.Pastore (Lamiaceae) on Intestinal Smooth Muscle.

, previously known as Benth., is used in folk medicine to relieve the symptoms of asthma, cough, and bronchitis. Recently, we showed that the ethanol extract obtained from has selective spasmolytic activity on guinea pig ileum.

Bioactive Compounds from the Aerial Parts of .

Three new caryophyllane-type sesquiterpenoids, linariophyllenes A-C (-), two new hamamelitol derivatives, linaritols A ( and B (), two new chromones, linariosides A () and B (), and three known chromones, cnidimol C (), monnieriside A (), and undulatoside A (), were identified from the aerial parts of . The structures of these compounds were elucidated by NMR, MS, and IR data. The absolute configurations of compounds - and were established via electronic circular dichroism data.

Flavonoids from (Taroda) J.S. Mill (cordiaceae) and the evaluation of spasmolytic activity of its crude ethanolic extract.

Pharmacological studies show spasmolytic activity for various species of . Thus, based on the taxonomy criteria, the aim of this study was to contribute to chemical and biological knowledge, especially regarding the evaluation of spasmolytic activity of the ethanolic extract from leaves (VD-EtOH) on rat aorta and trachea, guinea-pig ileum and rat uterus. Were used High and Medium Performance Liquid Chromatography.

Computer-Aided Chemotaxonomy and Bioprospecting Study of Diterpenes of the Lamiaceae Family.

Lamiaceae is one of the largest families of angiosperms and is classified into 12 subfamilies that are composed of 295 genera and 7775 species. It presents a variety of secondary metabolites such as diterpenes that are commonly found in their species, and some of them are known to be chemotaxonomic markers. The aim of this work was to construct a database of diterpenes and to use it to perform a chemotaxonomic analysis among the subfamilies of Lamiaceae, using molecular descriptors and self-organizing maps (SOMs).

Tri- and Diterpenoids from as Inhibitors of Zika Virus Replication.

This study represents the first phytochemical analysis of () and describes new terpenoids obtained from the root bark of this species. The fractionation of the hexane extract from the root bark led to the isolation of two new 28-nor-taraxarenes derivatives, loranthones A and B ( and ), four new tigliane diterpenes (-), three known tigliane diterpenes (-), and three known flexibilene diterpenes, tonantzitlolones A-C (-). The investigation of these compounds and the use of a molecular networking-based prioritization approach afforded two other new 28-nor-taraxarenes, loranthones C and D ( and ).

Dolastane diterpenes from and their effects in modulation of drug resistance in .

One new diterpene (4,7,14)-4α,7α-diacetoxy-10-one-14α-hydroxydolasta-1(15),8-diene (), and five known compounds (4,7,14)-4α,7α-diacetoxy-14α-hydroxydolasta-1(15),8-diene (), (4,14)-4α,14α-dihydroxydolasta-1(15),8-diene (), (4,9,14)-4α-acetoxy-9β,14α-dihydroxydolasta-1(15),7-diene (), 4-acetoxy-14-hydroxydolasta-1(15),7,9-triene () and isolinearol (), were isolated from . In this study, dolastane diterpenes were isolated from the alga and evaluated as modifiers of antibiotic activity in : SA-1199B, which overexpresses the norA gene RN-4220, which encodes for the protein efflux of macrolides (MRSA), and IS-58 which has the gene encoding the protein TetK. The minimum inhibitory concentrations (MICs) for norfloxacin, tetracycline and erythromycin were determined by the microdilution broth nutrient in the absence and presence of diterpenes at a sub-inhibitory concentration (MIC/4).

Solid-State Form Characterization of Riparin I.

Riparin I is an alkamide with potential anxiolytic activity in preclinical studies. The characterization and understanding of solid-state properties play an importance role in drug development. For this work, the solid state of five riparin I batches (RIP-1, RIP-2, RIP-3, RIP-4, and RIP-5), obtained by the same synthesis process, were characterized by Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), DSC-photovisual, Thermogravimetry (TG), Fourier Transform Infrared (FTIR), Pyrolysis (Pyr-GC/MS), X-ray Powder Diffraction (PXRD), and Solid-State Nuclear Magnetic Resonance (ssNMR) techniques.

Chemical composition and modulation of bacterial drug resistance of the essential oil from leaves of Croton grewioides.

The essential oil from leaves of Croton grewioides Baill was obtained by hydrodistillation using Clevenger apparatus, and its chemical composition was analyzed by GC-MS, where 18 compounds were identified, mostly as monoterpenes (55.56%) and sesquiterpenes (44.44%), in which the major constituent was the α-pinene (47.

Croton grewioides Baill. (Euphorbiaceae) Shows Antidiarrheal Activity in Mice.

Unlabelled: Based on chemotaxonomy, we decided to investigate the possible antidiarrheal activity in mice of a crude ethanolic extract obtained from aerial parts of Croton grewioides (CG-EtOH). We tested for any possible toxicity in rat erythrocytes and acute toxicity in mice. Antidiarrheal activity was assessed by determining the effect of CG-EtOH on defecation frequency, liquid stool, intestinal motility and intestinal fluid accumulation.

Essential oil from Xylopia frutescens Aubl. reduces cytosolic calcium levels on guinea pig ileum: mechanism underlying its spasmolytic potential.

Background: Xylopia frutescens Aubl. (embira, semente-de-embira or embira-vermelha), is used in folk medicine as antidiarrheal. The essential oil from its leaves (XF-EO) has been found to cause smooth muscle relaxation.